Breath and plasma metabolomics to assess inflammation in acute stroke

Ahmed, Waqar, White, Iain R, Wilkinson, Maxim, Johnson, Craig F, Rattray, Nicholas, Kishore, Amit K, Goodacre, Royston ORCID: 0000-0003-2230-645X, Smith, Craig J and Fowler, Stephen J (2021) Breath and plasma metabolomics to assess inflammation in acute stroke. SCIENTIFIC REPORTS, 11 (1). 21949-.

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Official URL: http://dx.doi.org/10.1038/s41598-021-01268-5

Abstract

Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.

Item Type:	Article
Uncontrolled Keywords:	Humans, Inflammation, C-Reactive Protein, Interleukin-6, Breath Tests, Feasibility Studies, Exhalation, Aged, Aged, 80 and over, Middle Aged, Female, Male, Stroke, Metabolomics, Biomarkers
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	22 Nov 2021 08:12
Last Modified:	26 Jan 2023 02:51
DOI:	10.1038/s41598-021-01268-5
Open Access URL:	https://www.nature.com/articles/s41598-021-01268-5
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3143502