Kosmicki, JA, Horowitz, JE, Banerjee, N, Lanche, R, Marcketta, A, Maxwell, E, Bai, X, Sun, D, Backman, JD, Sharma, D et al (show 72 more authors)
(2021)
A catalog of associations between rare coding variants and COVID-19 outcomes.
[Preprint]
Abstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19), a respiratory illness that can result in hospitalization or death. We investigated associations between rare genetic variants and seven COVID-19 outcomes in 543,213 individuals, including 8,248 with COVID-19. After accounting for multiple testing, we did not identify any clear associations with rare variants either exome-wide or when specifically focusing on (i) 14 interferon pathway genes in which rare deleterious variants have been reported in severe COVID-19 patients; (ii) 167 genes located in COVID-19 GWAS risk loci; or (iii) 32 additional genes of immunologic relevance and/or therapeutic potential. Our analyses indicate there are no significant associations with rare protein-coding variants with detectable effect sizes at our current sample sizes. Analyses will be updated as additional data become available, with results publicly browsable at https://rgc-covid19.regeneron.com.
Item Type: | Preprint |
---|---|
Uncontrolled Keywords: | Genetics, Rare Diseases, Vaccine Related, Prevention, Lung, Human Genome, Biodefense, 2.1 Biological and endogenous factors, 2 Aetiology, 3 Good Health and Well Being |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 30 Nov 2021 08:46 |
Last Modified: | 18 Mar 2024 03:20 |
DOI: | 10.1101/2020.10.28.20221804 |
Open Access URL: | https://www.medrxiv.org/content/10.1101/2020.10.28... |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3144195 |