A pilot study assessing the similarity between core outcome sets and outcomes included in health technology assessments.

Cox, Peter ORCID: 0000-0003-0549-759X, R Williamson, Paula and Dodd, Susanna ORCID: 0000-0003-2851-3337 (2021) A pilot study assessing the similarity between core outcome sets and outcomes included in health technology assessments. F1000Research, 10. 1084-.

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Official URL: http://dx.doi.org/10.12688/f1000research.73647.1

Abstract

Objective: Core outcome sets (COS) are an agreed standardised collection of outcomes created with representation from all key stakeholders (such as patients, clinicians, researchers), which should be reported as a minimum for all trials in that corresponding clinical area. There has been little research investigating the use of core outcomes in Health technology assessments (HTAs) and none in non-oncology HTAs. This study aimed to assess the similarity between COS and HTA outcomes. Methods: Ten COS published between 2015 and 2019 were selected, with patient participation taken as a proxy measure for a high quality COS. The INAHTA database was used as a source to identify relevant HTAs, which were accessed through the hyperlinks provided. Outcomes selected for these assessments were categorised as either a specific, partial or no match compared to the COS. An additional cohort of non-oncology HTAs published between 2019 and 2021 were identified from the NICE website and compared against a relevant COS. Results: Six hundred and fifty-one HTAs were matched to the ten COS areas, of which 119 were reviewed. Of a possible 1318 core outcome matches, there were 562 (43%) matches, 413 (31%) specific and 149 (11%) partial. NICE HTA matches against corresponding COS ranged from 44% to 100%, with a total of 78% (73/94) matches, 57 (61%) specific and 16 (17%) partial. Conclusion: Further work is required to promote the awareness and implementation of COS within HTAs. The degree of matching between COS and NICE HTA outcomes is encouraging, demonstrating acceptance of COS by HTA producers.

Item Type:	Article
Uncontrolled Keywords:	Humans, Pilot Projects, Publications, Databases, Factual, Technology Assessment, Biomedical, Outcome Assessment, Health Care
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Population Health
Depositing User:	Symplectic Admin
Date Deposited:	07 Dec 2021 10:25
Last Modified:	18 Jan 2023 21:23
DOI:	10.12688/f1000research.73647.2
Open Access URL:	http://doi.org/10.12688/f1000research.73647.1
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3144841