Vallet, Thibault, Bensouda, Yahya, Saito, Jumpei, Mathiesen, Liv, Pokharkar, Varsha, Klingmann, Viviane, Peak, Matthew, Elhamdaoui, Omar, Yamatani, Akimasa, Ivanovic, Ivana et al (show 7 more authors)
(2021)
Exploring Acceptability Drivers of Oral Antibiotics in Children: Findings from an International Observational Study.
PHARMACEUTICS, 13 (10).
1721-.
Abstract
Antibiotics are among the most commonly prescribed drugs in children. Adherence to the treatment with these drugs is of the utmost importance to prevent the emergence of resistant bacteria, a global health threat. In children, medicine acceptability is likely to have a significant impact on compliance. Herein we used a multivariate approach, considering simultaneously the many aspects of acceptability to explore the drivers of oral antibiotic acceptability in children under twelve, especially in toddlers and in preschoolers. Based on 628 real-life observer reports of the intake of 133 distinct medicines, the acceptability reference framework highlighted the influence of many factors such as age and sex of patients, previous exposure to treatment, place of administration, administration device, flavor agent in excipients and active pharmaceutical ingredient. These findings from an international observational study emphasize the multidimensional nature of acceptability. Therefore, it is crucial to consider all these different aspects for assessing this multi-faceted concept and designing or prescribing a medicine in order to reach adequate acceptability in the target population.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | acceptability, antibiotic, formulation, pediatric, children, ClinSearch acceptability score test (CAST) |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 08 Dec 2021 10:52 |
| Last Modified: | 18 Jan 2023 21:23 |
| DOI: | 10.3390/pharmaceutics13101721 |
| Open Access URL: | https://doi.org/10.3390/pharmaceutics13101721 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3144946 |
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