Wang, JunJie, Zhao, YiPing, Yu, AYong, Wu, Jie, Zhu, ManMan, Jiang, MuChen, Li, Xuefei, Zhu, DaTian, Zhang, PeiPei, Zheng, XiaoBo et al (show 2 more authors)
(2022)
Effect of travoprost, latanoprost and bimatoprost PGF2α treatments on the biomechanical properties of in-vivo rabbit cornea.
EXPERIMENTAL EYE RESEARCH, 215.
108920-.
Text
Evaluation of the influence of different kind s of PGF2α.pdf - Author Accepted Manuscript Download (1MB) | Preview |
Abstract
Prostaglandin F2α analogues (PGF2α), one of the most commonly prescribed classes of hypotensive agents, could decrease collagen fibril density and remodel the extracellular matrix in cornea. We hypothesized that PGF2α's would induce corneal softening, reduce the accuracy of intraocular pressure (IOP) measurement and lead to uncertainty in the effectiveness of the therapy. We determined the stress-strain behavior of rabbit cornea after PGF2α usage and evaluated the effect of biomechanical changes associated with PGF2α treatment on IOP measurements by Goldmann Applanation Tonometry (GAT). The tangent modulus decreased after PGF2α treatment, while the stromal interfibrillar spacing increased. PGF2α was shown to also affect the lateral eye with lower effect, which did not undergo direct eyedrop treatment. Significant decreases in the numerical predictions of GAT-IOP were predicted in all treated groups relative to control groups. Different PGF2α's (travoprost, latanoprost and bimatoprost) were associated with different extents of reduction in tissue stiffness and changes in corneal microstructure. PGF2α-induced changes in corneal mechanical properties could reduce the accuracy of IOP measurement and may cause an overestimation of the effect of PGF2α in lowering IOP, possibly leading to uncertainties in glaucoma management.
Item Type: | Article |
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Uncontrolled Keywords: | Prostaglandin, Cornea, Biomechanics |
Divisions: | Faculty of Science and Engineering > School of Engineering |
Depositing User: | Symplectic Admin |
Date Deposited: | 14 Jan 2022 13:56 |
Last Modified: | 17 Oct 2023 21:26 |
DOI: | 10.1016/j.exer.2022.108920 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3146156 |