Hamilton, William L ORCID: 0000-0002-3330-353X, Tonkin-Hill, Gerry ORCID: 0000-0003-4397-2224, Smith, Emily R ORCID: 0000-0003-4925-467X, Aggarwal, Dinesh ORCID: 0000-0002-5938-8172, Houldcroft, Charlotte J ORCID: 0000-0002-1833-5285, Warne, Ben ORCID: 0000-0003-1326-0373, Meredith, Luke W, Hosmillo, Myra ORCID: 0000-0002-3514-7681, Jahun, Aminu S ORCID: 0000-0002-4585-1701, Curran, Martin D et al (show 28 more authors)
(2021)
Genomic epidemiology of COVID-19 in care homes in the east of England.
eLife, 10.
e64618-.
Text
Genomic epidemiology of COVID-19 in care homes in the east of England.pdf - Published version Download (1MB) | Preview |
Abstract
COVID-19 poses a major challenge to care homes, as SARS-CoV-2 is readily transmitted and causes disproportionately severe disease in older people. Here, 1167 residents from 337 care homes were identified from a dataset of 6600 COVID-19 cases from the East of England. Older age and being a care home resident were associated with increased mortality. SARS-CoV-2 genomes were available for 700 residents from 292 care homes. By integrating genomic and temporal data, 409 viral clusters within the 292 homes were identified, indicating two different patterns - outbreaks among care home residents and independent introductions with limited onward transmission. Approximately 70% of residents in the genomic analysis were admitted to hospital during the study, providing extensive opportunities for transmission between care homes and hospitals. Limiting viral transmission within care homes should be a key target for infection control to reduce COVID-19 mortality in this population.
Item Type: | Article |
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Uncontrolled Keywords: | COVID-19 Genomics Consortium UK, Humans, Sequence Analysis, Disease Outbreaks, Polymorphism, Single Nucleotide, Time Factors, Aged, 80 and over, Nursing Homes, England, Female, Male, Infectious Disease Transmission, Professional-to-Patient, Infectious Disease Transmission, Patient-to-Professional, COVID-19, SARS-CoV-2 |
Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences |
Depositing User: | Symplectic Admin |
Date Deposited: | 15 Mar 2022 16:04 |
Last Modified: | 11 Mar 2023 02:56 |
DOI: | 10.7554/elife.64618 |
Related URLs: | |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3150638 |