Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets

Amewu, Richard Kwamla ORCID: 0000-0002-4676-436X, Sakyi, Patrick Opare, Osei-Safo, Dorcas and Addae-Mensah, Ivan
(2021) Synthetic and Naturally Occurring Heterocyclic Anticancer Compounds with Multiple Biological Targets. MOLECULES, 26 (23). 7134-.

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Cancer is a complex group of diseases initiated by abnormal cell division with the potential of spreading to other parts of the body. The advancement in the discoveries of omics and bio- and cheminformatics has led to the identification of drugs inhibiting putative targets including vascular endothelial growth factor (VEGF) family receptors, fibroblast growth factors (FGF), platelet derived growth factors (PDGF), epidermal growth factor (EGF), thymidine phosphorylase (TP), and neuropeptide Y4 (NY4), amongst others. Drug resistance, systemic toxicity, and drug ineffectiveness for various cancer chemo-treatments are widespread. Due to this, efficient therapeutic agents targeting two or more of the putative targets in different cancer cells are proposed as cutting edge treatments. Heterocyclic compounds, both synthetic and natural products, have, however, contributed immensely to chemotherapeutics for treatments of various diseases, but little is known about such compounds and their multimodal anticancer properties. A compendium of heterocyclic synthetic and natural product multitarget anticancer compounds, their IC<sub>50</sub>, and biological targets of inhibition are therefore presented in this review.

Item Type: Article
Uncontrolled Keywords: homeostasis, metastasis, angiogenesis, apoptosis, vascularization, heterocyclic compounds, multiple biological targets
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 11 May 2022 11:26
Last Modified: 03 Feb 2024 08:28
DOI: 10.3390/molecules26237134
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