Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium



Beyer, Katharina, Moris, Lisa, Lardas, Michael, Omar, Muhammad Imran, Healey, Jemma, Tripathee, Sheela, Gandaglia, Giorgio, Venderbos, Lionne DF, Vradi, Eleni, van den Broeck, Thomas
et al (show 23 more authors) (2022) Updating and Integrating Core Outcome Sets for Localised, Locally Advanced, Metastatic, and Nonmetastatic Castration-resistant Prostate Cancer: An Update from the PIONEER Consortium. EUROPEAN UROLOGY, 81 (5). pp. 503-514.

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Abstract

<h4>Context</h4>Harmonisation of outcome reporting and definitions for clinical trials and routine patient records can enable health care systems to provide more efficient outcome-driven and patient-centred interventions. We report on the work of the PIONEER Consortium in this context for prostate cancer (PCa).<h4>Objective</h4>To update and integrate existing core outcome sets (COS) for PCa for the different stages of the disease, assess their applicability, and develop standardised definitions of prioritised outcomes.<h4>Evidence acquisition</h4>We followed a four-stage process involving: (1) systematic reviews; (2) qualitative interviews; (3) expert group meetings to agree standardised terminologies; and (4) recommendations for the most appropriate definitions of clinician-reported outcomes.<h4>Evidence synthesis</h4>Following four systematic reviews, a multinational interview study, and expert group consensus meetings, we defined the most clinically suitable definitions for (1) COS for localised and locally advanced PCa and (2) COS for metastatic and nonmetastatic castration-resistant PCa. No new outcomes were identified in our COS for localised and locally advanced PCa. For our COS for metastatic and nonmetastatic castration-resistant PCa, nine new core outcomes were identified.<h4>Conclusions</h4>These are the first COS for PCa for which the definitions of prioritised outcomes have been surveyed in a systematic, transparent, and replicable way. This is also the first time that outcome definitions across all prostate cancer COS have been agreed on by a multidisciplinary expert group and recommended for use in research and clinical practice. To limit heterogeneity across research, these COS should be recommended for future effectiveness trials, systematic reviews, guidelines and clinical practice of localised and metastatic PCa.<h4>Patient summary</h4>Patient outcomes after treatment for prostate cancer (PCa) are difficult to compare because of variability. To allow better use of data from patients with PCa, the PIONEER Consortium has standardised and recommended outcomes (and their definitions) that should be collected as a minimum in all future studies.

Item Type: Article
Uncontrolled Keywords: Prostate cancer, Patient pathway, Comparative effectiveness research, Core outcome sets, Standardised outcome sets, Effectiveness trials, Outcomes, Randomised controlled trials, Systematic reviews, Big data, Real-world data
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Population Health
Depositing User: Symplectic Admin
Date Deposited: 16 May 2022 14:52
Last Modified: 18 Jan 2023 21:02
DOI: 10.1016/j.eururo.2022.01.042
Open Access URL: https://doi.org/10.1016/j.eururo.2022.01.042
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3154915