Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units – A high risk community-hospital interface



Li, Kathy K, Woo, Y Mun, Stirrup, Oliver, Hughes, Joseph, Ho, Antonia, Filipe, Ana Da Silva, Johnson, Natasha, Smollett, Katherine, Mair, Daniel, Carmichael, Stephen
et al (show 32 more authors) (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units – A high risk community-hospital interface. Journal of Infection, 83 (1). pp. 96-103.

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Abstract

<h4>Objectives</h4>Patients requiring haemodialysis are at increased risk of serious illness with SARS-CoV-2 infection. To improve the understanding of transmission risks in six Scottish renal dialysis units, we utilised the rapid whole-genome sequencing data generated by the COG-UK consortium.<h4>Methods</h4>We combined geographical, temporal and genomic sequence data from the community and hospital to estimate the probability of infection originating from within the dialysis unit, the hospital or the community using Bayesian statistical modelling and compared these results to the details of epidemiological investigations.<h4>Results</h4>Of 671 patients, 60 (8.9%) became infected with SARS-CoV-2, of whom 16 (27%) died. Within-unit and community transmission were both evident and an instance of transmission from the wider hospital setting was also demonstrated.<h4>Conclusions</h4>Near-real-time SARS-CoV-2 sequencing data can facilitate tailored infection prevention and control measures, which can be targeted at reducing risk in these settings.

Item Type: Article
Uncontrolled Keywords: COVID-19 Genomics UK (COG-UK) consortium, Humans, Renal Dialysis, Bayes Theorem, Hospitals, Molecular Epidemiology, COVID-19, SARS-CoV-2
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 19 May 2022 08:25
Last Modified: 16 Dec 2023 03:36
DOI: 10.1016/j.jinf.2021.04.020
Open Access URL: https://doi.org/10.1016/j.jinf.2021.04.020
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3155114