Molecular implications of HOX genes targeting multiple signaling pathways in cancer.

Shenoy, U Sangeetha, Adiga, Divya, Kabekkodu, Shama Prasada, Hunter, Keith D ORCID: 0000-0002-7873-0877 and Radhakrishnan, Raghu
(2021) Molecular implications of HOX genes targeting multiple signaling pathways in cancer. Cell biology and toxicology, 38 (1). pp. 1-30.

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Homeobox (HOX) genes encode highly conserved homeotic transcription factors that play a crucial role in organogenesis and tissue homeostasis. Their deregulation impacts the function of several regulatory molecules contributing to tumor initiation and progression. A functional bridge exists between altered gene expression of individual HOX genes and tumorigenesis. This review focuses on how deregulation in the HOX-associated signaling pathways contributes to the metastatic progression in cancer. We discuss their functional significance, clinical implications and ascertain their role as a diagnostic and prognostic biomarker in the various cancer types. Besides, the mechanism of understanding the theoretical underpinning that affects HOX-mediated therapy resistance in cancers has been outlined. The knowledge gained shall pave the way for newer insights into the treatment of cancer.

Item Type: Article
Uncontrolled Keywords: HOX genes, Diagnostic and prognostic significance, Signaling pathways, Metastasis, Cancer
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 24 May 2022 08:16
Last Modified: 05 May 2023 10:55
DOI: 10.1007/s10565-021-09657-2
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