Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review)

Qin, Shuguang, Tian, Zhenjun, Boidin, Maxime, Buckley, Benjamin JR ORCID: 0000-0002-1479-8872, Thijssen, Dick HJ and Lip, Gregory YH
(2022) Irisin is an Effector Molecule in Exercise Rehabilitation Following Myocardial Infarction (Review). FRONTIERS IN PHYSIOLOGY, 13. 935772-.

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<b>Background:</b> Regular exercise is an effective non-pharmacological therapy for treatment and prevention of cardiovascular disease (CVD). The therapeutic benefits of exercise are mediated partly through improved vascular and increase in metabolic health. Release of exercise-responsive myokines, including irisin, is associated with beneficial effects of exercise in CVD patients. <b>Observations:</b> The present review provides an overview of the role of exercise in cardiac rehabilitation of patients with myocardial infarction (MI). Further, the role of irisin as a motion-responsive molecule in improving vascular and metabolic health is explored. Possible mechanism of cardioprotective effect of irisin-mediated exercise on myocardial infarction are also summarized in this review. <b>Conclusion and significance of the review:</b> Irisin is associated with reduced inflammation, antioxidant properties, and anti-apoptotic effect, implying that it is a potential key mediator of the beneficial effects of exercise on vascular and metabolic health. The findings show that irisin is a promising therapeutic target for treatment of patients with cardiovascular disease, particularly post-MI. Further research should be conducted to elucidate the potential mechanisms of cardioprotective effects of irisin and explored whether irisin induced by exercise exerts rehabilitation effects post-MI.

Item Type: Article
Uncontrolled Keywords: irisin, exercise, myocardial infarction, cardiac rehabilitation, cardioprotection
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 06 Jun 2022 08:45
Last Modified: 18 Jan 2023 21:00
DOI: 10.3389/fphys.2022.935772
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