Gupta, Juhi K 
ORCID: 0000-0002-8292-9846 and Alfirevic, Ana ORCID: 0000-0002-2801-9817
(2022)
Systematic review of preterm birth multi-omic biomarker studies.
EXPERT REVIEWS IN MOLECULAR MEDICINE, 24.
pp. 1-24.
Abstract
Preterm birth (PTB) is one of the leading causes of deaths in infants under the age of five. Known risk factors of PTB include genetic factors, lifestyle choices or infection. Identification of omic biomarkers associated with PTB could aid clinical management of women at high risk of early labour and thereby reduce neonatal morbidity. This systematic literature review aimed to identify and summarise maternal omic and multi-omic (genomics, transcriptomics, proteomics and metabolites) biomarker studies of PTB. Original research articles were retrieved from three databases: PubMed, Web of Science and Science Direct, using specified search terms for each omic discipline. PTB studies investigating genomics, transcriptomics, proteomics or metabolomics biomarkers prior to onset of labour were included. Data were collected and reviewed independently. Pathway analyses were completed on the biomarkers from non-targeted omic studies using Reactome pathway analysis tool. A total of 149 omic studies were identified; most of the literature investigated proteomic biomarkers. Pathway analysis identified several cellular processes associated with the omic biomarkers reported in the literature. Study heterogeneity was observed across the research articles, including the use of different gestation cut-offs to define PTB. Infection/inflammatory biomarkers were identified across majority of papers using a range of targeted and non-targeted approaches.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Epigenetics, genomics, maternal biomarkers, metabolomics, multi-omics, omics, preterm birth, preterm labour, proteomics, transcriptomics |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 07 Jun 2022 09:18 |
| Last Modified: | 17 Feb 2023 01:29 |
| DOI: | 10.1017/erm.2022.13 |
| Open Access URL: | https://doi.org/10.1017/erm.2022.13 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3155989 |
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