Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle

Jackson, Malcolm J ORCID: 0000-0003-3683-8297, Pollock, Natalie, Staunton, Caroline ORCID: 0000-0003-0647-3063, Jones, Samantha and McArdle, Anne
(2022) Redox Control of Signalling Responses to Contractile Activity and Ageing in Skeletal Muscle. CELLS, 11 (10). 1698-.

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Research over almost 40 years has established that reactive oxygen species are generated at different sites in skeletal muscle and that the generation of these species is increased by various forms of exercise. Initially, this was thought to be potentially deleterious to skeletal muscle and other tissues, but more recent data have identified key roles of these species in muscle adaptations to exercise. The aim of this review is to summarise our current understanding of these redox signalling roles of reactive oxygen species in mediating responses of muscle to contractile activity, with a particular focus on the effects of ageing on these processes. In addition, we provide evidence that disruption of the redox status of muscle mitochondria resulting from age-associated denervation of muscle fibres may be an important factor leading to an attenuation of some muscle responses to contractile activity, and we speculate on potential mechanisms involved.

Item Type: Article
Uncontrolled Keywords: contraction, muscle, sarcopenia
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 04 Jul 2022 10:08
Last Modified: 18 Jan 2023 20:56
DOI: 10.3390/cells11101698
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