Clinical standards for drug-susceptible pulmonary TB



Akkerman, OW, Duarte, R, Tiberi, S, Schaaf, HS, Lange, C, Alffenaar, JWC, Denholm, J, Carvalho, ACC, Bolhuis, MS, Borisov, S
et al (show 37 more authors) (2022) Clinical standards for drug-susceptible pulmonary TB. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 26 (7). pp. 592-604.

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Abstract

<b>BACKGROUND:</b> The aim of these clinical standards is to provide guidance on 'best practice´ for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB).<b>METHODS:</b> A panel of 54 global experts in the field of TB care, public health, microbiology, and pharmacology were identified; 46 participated in a Delphi process. A 5-point Likert scale was used to score draft standards. The final document represents the broad consensus and was approved by all 46 participants.<b>RESULTS:</b> Seven clinical standards were defined: Standard 1, all patients (adult or child) who have symptoms and signs compatible with PTB should undergo investigations to reach a diagnosis; Standard 2, adequate bacteriological tests should be conducted to exclude drug-resistant TB; Standard 3, an appropriate regimen recommended by WHO and national guidelines for the treatment of PTB should be identified; Standard 4, health education and counselling should be provided for each patient starting treatment; Standard 5, treatment monitoring should be conducted to assess adherence, follow patient progress, identify and manage adverse events, and detect development of resistance; Standard 6, a recommended series of patient examinations should be performed at the end of treatment; Standard 7, necessary public health actions should be conducted for each patient. We also identified priorities for future research into PTB.<b>CONCLUSION:</b> These consensus-based clinical standards will help to improve patient care by guiding clinicians and programme managers in planning and implementation of locally appropriate measures for optimal person-centred treatment for PTB.

Item Type: Article
Uncontrolled Keywords: pulmonary TB, management, diagnosis, treatment, education, rehabilitation, clinical standards
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 18 Oct 2022 15:38
Last Modified: 15 Mar 2024 21:20
DOI: 10.5588/ijtld.22.0228
Open Access URL: https://doi.org/10.5588/ijtld.22.0228
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3165635