Gregory, Georgina L and Copple, Ian M 
ORCID: 0000-0003-4101-1913
(2023)
Modulating the expression of tumor suppressor genes using activating oligonucleotide technologies as a therapeutic approach in cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS, 31.
pp. 211-223.
Abstract
Tumor suppressor genes (TSGs) are frequently downregulated in cancer, leading to dysregulation of the pathways that they control. The continuum model of tumor suppression suggests that even subtle changes in TSG expression, for example, driven by epigenetic modifications or copy number alterations, can lead to a loss of gene function and a phenotypic effect. This approach to exploring tumor suppression provides opportunities for alternative therapies that may be able to restore TSG expression toward normal levels, such as oligonucleotide therapies. Oligonucleotide therapies involve the administration of exogenous nucleic acids to modulate the expression of specific endogenous genes. This review focuses on two types of activating oligonucleotide therapies, small-activating RNAs and synthetic mRNAs, as novel methods to increase the expression of TSGs in cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MT: oligonucleotides: therapies and applications, cancer, mRNA, oligonucleotide, saRNA, tumor suppressor gene |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 17 Jan 2023 14:30 |
| Last Modified: | 15 Sep 2023 09:21 |
| DOI: | 10.1016/j.omtn.2022.12.016 |
| Open Access URL: | https://www.cell.com/molecular-therapy-family/nucl... |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3167099 |
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