Acute Pancreatitis in Childhood A 10-Year Experience From A Thai University Surgical Center



Boonthai, Ampaipan, Tanpowpong, Pornthep, Puttanapitak, Chawintee, Aeesoa, Suraida, Losty, Paul D ORCID: 0000-0003-0841-5879 and Molagool, Sani
(2022) Acute Pancreatitis in Childhood A 10-Year Experience From A Thai University Surgical Center. PANCREAS, 51 (7). pp. 808-813.

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Abstract

<h4>Objectives</h4>This study aimed to describe etiology, management, and health outcomes of children developing acute pancreatitis at a tertiary Thailand pediatric surgery center.<h4>Methods</h4>Medical case records of all index cases during 2006-2016 were analyzed and reported.<h4>Results</h4>There were 42 male and 37 female patients, with a mean (standard deviation) age of 10.4 (4.5) years, included in the study. Medications were the commonest etiology for 39.3% of acute pancreatitis attacks, 11.4% for biliary tract disease cases, and 8% for postinterventional studies. In 30% of cases, no cause(s) was defined. Sixty-two patients (78.5%) had elevated serum lipase on hospital admission, whereas only 30.4% showed a raised amylase. Hospital stay was 15 days (interquartile range, 6-27 days). Two major complications in the series were pseudocysts (8.8%) and necrotizing pancreatitis (7.6%). Etiological factors and/or antibiotics were not directly linked to any specific complications. Seventeen children (22.8%) had 1 recurrent episode of acute pancreatitis documented. Mortality rate in index cases was 28%, with a higher percentage harboring a preexisting illness (34.4% vs 5.6%; P = 0.01) and in male than in female patients (41% vs 14%; P = 0.01).<h4>Conclusions</h4>Deaths from pediatric acute pancreatitis are more prevalent in male individuals and those with a preexisting illness. Targeted strategies aimed at "highest-risk" patients may potentially offset mortality.

Item Type: Article
Uncontrolled Keywords: acute pancreatitis, pediatrics, lipase, amylase, pseudocyst, mortality
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 01 Feb 2023 11:42
Last Modified: 17 Mar 2024 15:39
DOI: 10.1097/MPA.0000000000002109
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3168068