Clinical overview of diabetes mellitus as a risk factor for cardiovascular death

Abuelgasim, Eyad, Shah, Suleyman, Abuelgasim, Biyaser, Soni, Nikita, Thomas, Ashvin, Elgasim, Mustafa and Harky, Amer ORCID: 0000-0001-5507-5841
(2021) Clinical overview of diabetes mellitus as a risk factor for cardiovascular death. REVIEWS IN CARDIOVASCULAR MEDICINE, 22 (2). pp. 301-314.

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Global diabetes mellitus prevalence is increasing. Metabolic disorders, such as type 2 diabetes, are associated with abnormal cardiac electrophysiology and increased risk of arrhythmias. Patients with both diabetes types (1 and 2) suffer from sudden cardac death (SCD) as a leading cause of mortality. Cardiovascular death is defined as death attributable to cardiovascular disease (CVD) occurring shortly within the symptom onset. This usually arises from life-threatening ventricular tachyarrhythmias that lead to hemodynamic instability, and subsequent shock and death. A variety of pathways have been suggested that link hypoglycaemia to the development of adverse cardiovascular outcomes, including blood coagulation abnormalities, inflammation, endothelial dysfunction and sympathoadrenal responses. We propose a four-step framework for the optimisation of SCD risk factors in diabetic patients, to include: raising awareness to influence health behaviour, provision of screening programs, use of technology within educational programs to improve patient engagement and effective provision of diabetic community teams.

Item Type: Article
Uncontrolled Keywords: Diabetes mellitus, Cardiovascular disease, Sudden cardiac death, Hypoglycaemia, Cardiomyopathy
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 02 Feb 2023 15:47
Last Modified: 02 Feb 2023 15:47
DOI: 10.31083/j.rcm2202038
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