Hydrogenation of functionalised pyridines with a rhodium oxide catalyst under mild conditions.



Williams, Sydney, Qi, Leiming, Cox, Robert J, Kumar, Prashant and Xiao, Jianliang ORCID: 0000-0003-2010-247X
(2024) Hydrogenation of functionalised pyridines with a rhodium oxide catalyst under mild conditions. Organic & biomolecular chemistry, 22 (5). pp. 1010-1017.

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Abstract

Piperidines are one of the most widely used building blocks in the synthesis of pharmaceutical and agrochemical compounds. The hydrogenation of pyridines is a convenient method to synthesise such compounds as it only requires reactant, catalyst, and a hydrogen source. However, this reaction still remains difficult for the reduction of functionalised and multi-substituted pyridines. Here we report the use of a stable, commercially available rhodium compound, Rh<sub>2</sub>O<sub>3</sub>, for the reduction of various unprotected pyridines. The reaction only requires mild conditions, and the substrate scope is broad, making it practically useful.

Item Type: Article
Divisions: Faculty of Science and Engineering > School of Physical Sciences
Depositing User: Symplectic Admin
Date Deposited: 26 Jan 2024 08:13
Last Modified: 03 Feb 2024 02:07
DOI: 10.1039/d3ob01860a
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3178040