Modification of nanodiamonds for fluorescence bioimaging.



Fryer, Claudia, Murray, Patricia and Zhang, Haifei
(2024) Modification of nanodiamonds for fluorescence bioimaging. RSC advances, 14 (7). pp. 4633-4644.

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Abstract

Non-invasive bioimaging is essential in enhancing pre-clinical diagnosis and therapy. Developing efficient imaging probes with high stability, low toxicity, and the potential of offering high resolution images is a very important aspect of developing non-invasive bioimaging techniques. Fluorescent nanodiamonds, which are produced by high energy beam irradiation and high temperature/pressure treatment, have been extensively investigated. In this study, we report the chemical modification of common nanodiamonds (prepared by detonation and high-pressure high-temperature milling) using a stable fluorophore (perylene diimide derivative) <i>via</i> carbodiimide coupling. The resulting nanodiamonds show good biocompatibility, cellular uptake and fluorescent imaging potential with mesenchymal stromal cells. This method provides an efficient alternative approach to the preparation and the use of fluorescent nanodiamonds for bioimaging, with the potential benefit of chemically adjusting the structure of perylene diimide for optimized emission/absorbance wavelength.

Item Type: Article
Uncontrolled Keywords: 34 Chemical Sciences, Bioengineering
Divisions: Faculty of Health and Life Sciences
Faculty of Science and Engineering > School of Physical Sciences
Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User: Symplectic Admin
Date Deposited: 13 Feb 2024 10:56
Last Modified: 20 Jun 2024 21:02
DOI: 10.1039/d3ra08762j
Open Access URL: https://doi.org/10.1039/D3RA08762J
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3178624