Multi-layered genome defences in bacteria.

Agapov, Aleksei, Baker, Kate S ORCID: 0000-0001-5850-1949, Bedekar, Paritosh, Bhatia, Rama P, Blower, Tim R, Brockhurst, Michael A, Brown, Cooper, Chong, Charlotte E, Fothergill, Joanne L ORCID: 0000-0002-7012-1508, Graham, Shirley
et al (show 15 more authors) (2024) Multi-layered genome defences in bacteria. Current opinion in microbiology, 78. p. 102436.

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Bacteria have evolved a variety of defence mechanisms to protect against mobile genetic elements, including restriction-modification systems and CRISPR-Cas. In recent years, dozens of previously unknown defence systems (DSs) have been discovered. Notably, diverse DSs often coexist within the same genome, and some co-occur at frequencies significantly higher than would be expected by chance, implying potential synergistic interactions. Recent studies have provided evidence of defence mechanisms that enhance or complement one another. Here, we review the interactions between DSs at the mechanistic, regulatory, ecological and evolutionary levels.

Item Type: Article
Uncontrolled Keywords: Bacteria, Bacteriophages, Biological Evolution, CRISPR-Cas Systems
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 04 Mar 2024 09:33
Last Modified: 22 Mar 2024 00:45
DOI: 10.1016/j.mib.2024.102436
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