Polydopamine-Coated Polymer Nanofibers for In Situ Protein Loading and Controlled Release.



Zhang, Meina, Dop, Romy A ORCID: 0000-0002-3903-7236 and Zhang, Haifei ORCID: 0000-0001-5142-5824
(2024) Polydopamine-Coated Polymer Nanofibers for In Situ Protein Loading and Controlled Release. ACS omega, 9 (12). pp. 14465-14474.

Access the full-text of this item by clicking on the Open Access link.

Abstract

Nanofibrous polymeric materials, combined with protein therapeutics, play a significant role in biomedical and pharmaceutical applications. However, the upload of proteins into nanofibers with a high yield and controlled release has been a challenging issue. Here, we report the in situ loading of a model protein (bovine serum albumin) into hydrophilic poly(vinyl alcohol) nanofibers via ice-templating, with a 100% protein drug loading efficiency. These protein-loaded nanofibers were further coated by polydopamine in order to improve the nanofiber stability and achieve a controlled protein release. The mass ratio between poly(vinyl alcohol) and bovine serum albumin influenced the percentage of proteins in composite nanofibers and fiber morphology. More particles and less nanofibers were formed with an increasing percentage of bovine serum albumin. By varying the coating conditions, it was possible to produce a uniform polydopamine coating with tunable thickness, which acted as an additional barrier to reduce burst release and achieve a more sustained release profile.

Item Type: Article
Uncontrolled Keywords: 40 Engineering, 4003 Biomedical Engineering, Nanotechnology, Bioengineering
Divisions: Faculty of Health and Life Sciences
Faculty of Science and Engineering > School of Physical Sciences
Faculty of Health and Life Sciences > Institute of Infection, Veterinary and Ecological Sciences
Depositing User: Symplectic Admin
Date Deposited: 16 Apr 2024 07:55
Last Modified: 15 Jun 2024 02:47
DOI: 10.1021/acsomega.4c00263
Open Access URL: https://doi.org/10.1021/acsomega.4c00263
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3180365