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Number of items: 19.


Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E, Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P ORCID: 0000-0002-0758-3152, Park, B Kevin ORCID: 0000-0001-8384-824X and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2019) Acute Metabolic Switch Assay Using Glucose/Galactose Medium in HepaRG Cells to Detect Mitochondrial Toxicity. Current protocols in toxicology, 80 (01). e76-.


Penman, Sophie L ORCID: 0000-0001-5326-1675, Jensen, Rebecca L ORCID: 0000-0003-1134-2869, Kiy, Robyn T ORCID: 0000-0001-7960-7283 and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2020) Anti-Cancer Drugs: The mitochondrial paradox. eLife, 9. e59140-.


Ball, Amy L, Bloch, Katarzyna M, Rainbow, Lucille ORCID: 0000-0003-0447-6885, Liu, Xuan, Kenny, John, Lyon, Jonathan J, Gregory, Richard, Alfirevic, Ana ORCID: 0000-0002-2801-9817 and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2021) Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers. Archives of Toxicology, 95 (4). pp. 1335-1347.


Thaventhiran, Thilipan, Wong, Wai, Alghanem, Ahmad F, Alhumeed, Naif ORCID: 0000-0001-5221-3073, Aljasir, Mohammad A, Ramsey, Simeon, Sethu, Swaminathan ORCID: 0000-0001-9210-2554, Yeang, Han Xian Aw, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Cross, Michael ORCID: 0000-0002-5533-1232 et al (show 5 more authors) (2019) CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program. Monoclonal antibodies in immunodiagnosis and immunotherapy, 38 (2). pp. 60-69.


Bin Dayel, Faten F ORCID: 0009-0006-8181-8374, Alfirevic, Ana ORCID: 0000-0002-2801-9817 and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2023) Developing In Vitro Models to Define the Role of Direct Mitochondrial Toxicity in Frequently Reported Drug-Induced Rhabdomyolysis. Biomedicines, 11 (5). p. 1485.


Penman, Sophie L ORCID: 0000-0001-5326-1675, Sharma, Parveen, Aerts, Helene, Park, B Kevin ORCID: 0000-0001-8384-824X, Weaver, Richard J and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2019) Differential toxic effects of bile acid mixtures in isolated mitochondria and physiologically relevant HepaRG cells. TOXICOLOGY IN VITRO, 61. 104595-.


Heaton, Bethany J ORCID: 0000-0002-1495-1945, Jensen, Rebecca L ORCID: 0000-0003-1134-2869, Line, James ORCID: 0000-0003-3568-8928, David, Christopher AW ORCID: 0000-0001-8504-2354, Brain, Danielle E ORCID: 0000-0002-1671-8477, Chadwick, Amy E ORCID: 0000-0002-7399-8655 and Liptrott, Neill J ORCID: 0000-0002-5980-8966 (2022) Exposure of human immune cells, to the antiretrovirals efavirenz and lopinavir, leads to lower glucose uptake and altered bioenergetic cell profiles through interactions with SLC2A1. BIOMEDICINE & PHARMACOTHERAPY, 150. 112999-.


Gardner, Joshua ORCID: 0000-0002-4520-108X, Hammond, Sean, Jensen, Rebecca ORCID: 0000-0003-1134-2869, Gibson, Andrew, Krantz, Matthew S, Ardern-Jones, Michael, Phillips, Elizabeth J, Pirmohamed, Munir ORCID: 0000-0002-7534-7266, Chadwick, Amy E, Betts, Catherine et al (show 1 more authors) (2024) Glycolysis: An early marker for vancomycin-specific T-cell activation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.


Gardner, Joshua ORCID: 0000-0002-4520-108X, Hammond, Sean, Jensen, Rebecca ORCID: 0000-0003-1134-2869, Gibson, Andrew, Krantz, Matthew S, Ardern-Jones, Michael, Phillips, Elizabeth J, Pirmohamed, Munir ORCID: 0000-0002-7534-7266, Chadwick, Amy E, Betts, Catherine et al (show 1 more authors) (2024) Glycolysis: An early marker for vancomycin-specific T-cell activation. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 54 (1). pp. 21-33.


Leedale, Joseph ORCID: 0000-0001-9010-4126, Colley, Helen E, Gaskell, Harriet, Williams, Dominic P ORCID: 0000-0002-0758-3152, Bearon, Rachel N ORCID: 0000-0001-8461-0823, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Murdoch, Craig ORCID: 0000-0003-0053-7468 and Webb, Steven D (2019) In silico-guided optimisation of oxygen gradients in hepatic spheroids. Computational Toxicology, 12. p. 100093.


Jones, Samantha W, Penman, Sophie L ORCID: 0000-0001-5326-1675, French, Neil S ORCID: 0000-0002-9376-3482, Park, B Kevin ORCID: 0000-0001-8384-824X and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2021) Investigating dihydroorotate dehydrogenase inhibitor mediated mitochondrial dysfunction in hepatic in vitro models. Toxicology in Vitro, 72. p. 105096.


Penman, Sophie L ORCID: 0000-0001-5326-1675, Carter, Alice S and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2020) Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity. Biochemical Society Transactions, 48 (3). pp. 787-797.


Weaver, Richard J, Blomme, Eric A, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Copple, Ian M ORCID: 0000-0003-4101-1913, Gerets, Helga HJ, Goldring, Christopher E, Guillouzo, Andre, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig et al (show 12 more authors) (2020) Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models. NATURE REVIEWS DRUG DISCOVERY, 19 (2). pp. 131-148.


Kelly, Ross A, Leedale, Joseph A ORCID: 0000-0001-9010-4126, Harrell, Andy, Beard, Daniel A, Randle, Laura E ORCID: 0000-0002-7881-2979, Chadwick, Amy E ORCID: 0000-0002-7399-8655 and Webb, Steven D (2018) Modelling the impact of changes in the extracellular environment on the cytosolic free NAD+/NADH ratio during cell culture. PLoS One, 13 (11). e0207803-.


Jones, Samantha W, Ball, Amy L, Chadwick, Amy E ORCID: 0000-0002-7399-8655 and Alfirevic, Ana ORCID: 0000-0002-2801-9817 (2021) The Role of Mitochondrial DNA Variation in Drug Response: A Systematic Review. Frontiers in Genetics, 12. 698825-.


Penman, Sophie L ORCID: 0000-0001-5326-1675, Kiy, Robyn T ORCID: 0000-0001-7960-7283, Jensen, Rebecca L ORCID: 0000-0003-1134-2869, Beoku‐Betts, Christopher, Alfirevic, Ana ORCID: 0000-0002-2801-9817, Back, David, Khoo, Saye H, Owen, Andrew ORCID: 0000-0002-9819-7651, Pirmohamed, Munir ORCID: 0000-0002-7534-7266, Park, B Kevin ORCID: 0000-0001-8384-824X et al (show 3 more authors) (2020) Safety perspectives on presently considered drugs for the treatment of COVID‐19. British Journal of Pharmacology, 177 (19). pp. 4353-4374.


Ball, Amy Louise, Jolly, Carol E ORCID: 0000-0002-4663-862X, Lennon, Mark G, Lyon, Jonathan J, Alfirevic, Ana ORCID: 0000-0002-2801-9817 and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2023) The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury. ELIFE, 12. e78187-.


Kamalian, Laleh, Douglas, Oisin, Jolly, Carol E, Snoeys, Jan, Simic, Damir, Monshouwer, Mario, Williams, Dominic P ORCID: 0000-0002-0758-3152, Park, B Kevin ORCID: 0000-0001-8384-824X and Chadwick, Amy E ORCID: 0000-0002-7399-8655 (2018) The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity. TOXICOLOGY IN VITRO, 53. pp. 136-147.


Jolly, Carol E, Douglas, Oisin, Kamalian, Laleh, Jenkins, Rosalind E, Beckett, Alison J ORCID: 0000-0001-8377-325X, Penman, Sophie L ORCID: 0000-0001-5326-1675, Williams, Dominic P ORCID: 0000-0002-0758-3152, Monshouwer, Mario, Simic, Damir, Snoeys, Jan et al (show 2 more authors) (2020) The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine. Toxicology and applied pharmacology, 403. 115163-.

This list was generated on Sun Jan 21 08:37:02 2024 GMT.