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Soares, Pedro, Gadd, Morgan S, Frost, Julianty ORCID: 0000-0001-8209-2575, Galdeano, Carles, Ellis, Lucy, Epemolu, Ola, Rocha, Sonia, Read, Kevin D and Ciulli, Alessio
(2018) Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyI)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyppyrrolidine-2-carboxamide (VH298). JOURNAL OF MEDICINAL CHEMISTRY, 61 (2). 599 - 618.


Maniaci, Chiara, Hughes, Scott J, Testa, Andrea, Chen, Wenzhang, Lamont, Douglas J, Rocha, Sonia, Alessi, Dario R, Romeo, Roberto and Ciulli, Alessio
(2017) Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nature communications, 8.


Frost, Julianty ORCID: 0000-0001-8209-2575, Galdeano, Carles, Soares, Pedro, Gadd, Morgan S, Grzes, Katarzyna M, Ellis, Lucy, Epemolu, Ola, Shimamura, Satoko, Bantscheff, Marcus, Grandi, Paola
et al (show 4 more authors) (2016) Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nature communications, 7.


Frost, Julianty, Ciulli, Alessio ORCID: 0000-0002-8654-1670 and Rocha, Sonia ORCID: 0000-0002-2413-4981
(2019) RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response. Wellcome open research, 4. 17 - ?.


Frost, Julianty ORCID: 0000-0001-8209-2575, Rocha, Sonia and Ciulli, Alessio
(2021) Von Hippel-Lindau (VHL) small-molecule inhibitor binding increases stability and intracellular levels of VHL protein. JOURNAL OF BIOLOGICAL CHEMISTRY, 297 (2).

This list was generated on Thu Nov 25 03:41:58 2021 GMT.