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Dickens, David ORCID: 0000-0001-8295-0752, Rädisch, Steffen, Chiduza, George N ORCID: 0000-0003-1037-5749, Giannoudis, Athina ORCID: 0000-0002-7200-1497, Cross, Michael J ORCID: 0000-0002-5533-1232, Malik, Hassan, Schaeffeler, Elke, Sison-Young, Rowena L, Wilkinson, Emma L, Goldring, Christopher E et al (show 3 more authors)
(2018)
Cellular Uptake of the Atypical Antipsychotic Clozapine Is a Carrier-Mediated Process.
Molecular Pharmaceutics, 15 (8).
pp. 3557-3572.
Copple, Ian M ORCID: 0000-0003-4101-1913, den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E, Maggs, James L, Schofield, Amy L, Rainbow, Lucille ORCID: 0000-0003-0447-6885, Fang, Yongxiang ORCID: 0000-0002-4514-5292, Sutherland, Jeffrey J, Ellis, Ewa C et al (show 6 more authors)
(2019)
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Archives of Toxicology, 93 (2).
pp. 385-399.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Faulkner, Lee, Jenkins, Roz E, French, Neil S ORCID: 0000-0002-9376-3482, Copple, Ian M ORCID: 0000-0003-4101-1913, Antoine, Daniel J, Elmasry, Mohamed, Malik, Hasan, Goldring, Christopher E, Park, Brian Kevin ORCID: 0000-0001-8384-824X et al (show 2 more authors)
(2017)
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.
TOXICOLOGICAL SCIENCES, 158 (1).
pp. 76-89.
Arshad, Usman ORCID: 0000-0003-1586-1885, Sutton, Paul A, Ashford, Marianne B, Treacher, Kevin E, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Rannard, Steve P ORCID: 0000-0002-6946-1097, Goldring, Christopher E and Owen, Andrew ORCID: 0000-0002-9819-7651
(2020)
Critical considerations for targeting colorectal liver metastases with nanotechnology.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 12 (2).
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Wong, Michael HL, Bryan, Holly K, Copple, Ian M ORCID: 0000-0003-4101-1913, Jenkins, Rosalind E, Chiu, Pak Him, Bibby, Jaclyn, Berry, Neil G ORCID: 0000-0003-1928-0738, Kitteringham, Neil R, Goldring, Christopher E, O'Neill, Paul M ORCID: 0000-0003-4338-0317 et al (show 1 more authors)
(2016)
Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites.
JOURNAL OF MEDICINAL CHEMISTRY, 59 (6).
pp. 2396-2409.
Evans, Jonathan P, Winiarski, Boleslaw K, Sutton, Paul A, Ressel, Lorenzo ORCID: 0000-0002-6614-1223, Duckworth, Carrie A ORCID: 0000-0001-9992-7540, Pritchard, D Mark ORCID: 0000-0001-7971-3561, Palmer, Daniel H ORCID: 0000-0002-7147-5703, Goldring, Christopher E and Kitteringham, Neil R
(2019)
Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.
LABORATORY ANIMALS, 53 (6).
pp. 598-609.
Copple, Ian M ORCID: 0000-0003-4101-1913, Park, B Kevin ORCID: 0000-0001-8384-824X and Goldring, Christopher E
(2021)
Gene signatures reduce the stress of preclinical drug hepatotoxicity screening.
Hepatology (Baltimore, Md.), 74 (1).
pp. 513-515.
Weaver, Richard J, Blomme, Eric A, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Copple, Ian M ORCID: 0000-0003-4101-1913, Gerets, Helga HJ, Goldring, Christopher E, Guillouzo, Andre, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig et al (show 12 more authors)
(2020)
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
NATURE REVIEWS DRUG DISCOVERY, 19 (2).
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Howell, Lawrence S, Ireland, Lucy, Park, B Kevin ORCID: 0000-0001-8384-824X and Goldring, Christopher E
(2018)
MiR-122 and other microRNAs as potential circulating biomarkers of drug-induced liver injury.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 18 (1).
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Khamina, Kseniya, Diendorfer, Andreas B, Skalicky, Susanna, Weigl, Moritz, Pultar, Marianne, Krammer, Teresa L, Fournier, Catharine Aquino, Schofield, Amy L, Otto, Carolin, Smith, Aaron Thomas et al (show 12 more authors)
(2022)
A MicroRNA Next-Generation-Sequencing Discovery Assay (miND) for Genome-Scale Analysis and Absolute Quantitation of Circulating MicroRNA Biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23 (3).
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Oppelt, Angela, Kaschek, Daniel, Huppelschoten, Suzanna, Sison-Young, Rowena, Zhang, Fang, Buck-Wiese, Marie, Herrmann, Franziska, Malkusch, Sebastian, Kruger, Carmen L, Meub, Mara et al (show 12 more authors)
(2018)
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4 (1).
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Lister, Adam, Bourgeois, Soline, Silva, Pedro H Imenez, Rubio-Aliaga, Isabel, Marbet, Philippe, Walsh, Joanne, Shelton, Luke M, Keller, Bettina, Verrey, Francois, Devuyst, Olivier et al (show 6 more authors)
(2018)
NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.
SCIENTIFIC REPORTS, 8 (1).
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Chan, Benjamin KY, Elmasry, Mohamed, Forootan, Shiva S, Russomanno, Giusy ORCID: 0000-0002-3378-5524, Bunday, Tobias M, Zhang, Fang, Brillant, Nathalie, Lewis, Philip J Starkey, Aird, Rhona, Ricci, Emanuele ORCID: 0000-0001-9751-0661 et al (show 14 more authors)
(2021)
Pharmacological Activation of Nrf2 Enhances Functional Liver Regeneration.
HEPATOLOGY, 74 (2).
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Forootan, Shiva S, Mutter, Fiona E, Kipar, Anja ORCID: 0000-0001-7289-3459, Iwawaki, Takao, Francis, Ben ORCID: 0000-0002-2130-5976, Goldring, Christopher E, Park, B Kevin ORCID: 0000-0001-8384-824X and Copple, Ian M ORCID: 0000-0003-4101-1913
(2017)
Real-time in vivo imaging reveals localised Nrf2 stress responses associated with direct and metabolism-dependent drug toxicity.
SCIENTIFIC REPORTS, 7 (1).
Penman, Sophie L ORCID: 0000-0001-5326-1675, Kiy, Robyn T ORCID: 0000-0001-7960-7283, Jensen, Rebecca L ORCID: 0000-0003-1134-2869, Beoku‐Betts, Christopher, Alfirevic, Ana ORCID: 0000-0002-2801-9817, Back, David, Khoo, Saye H, Owen, Andrew ORCID: 0000-0002-9819-7651, Pirmohamed, Munir ORCID: 0000-0002-7534-7266, Park, B Kevin ORCID: 0000-0001-8384-824X et al (show 3 more authors)
(2020)
Safety perspectives on presently considered drugs for the treatment of COVID‐19.
British Journal of Pharmacology, 177 (19).
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Thulin, Petra, Hornby, Robert J, Auli, Mariona, Nordahl, Gunnar, Antoine, Daniel J, Lewis, Philip Starkey, Goldring, Christopher E, Park, B Kevin ORCID: 0000-0001-8384-824X, Prats, Neus, Glinghammar, Bjorn et al (show 1 more authors)
(2017)
A longitudinal assessment of miR-122 and GLDH as biomarkers of drug-induced liver injury in the rat.
BIOMARKERS, 22 (5).
pp. 461-469.
Russomanno, Giusy ORCID: 0000-0002-3378-5524, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciaran P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H et al (show 12 more authors)
(2023)
A systems approach reveals species differences in hepatic stress response capacity.
TOXICOLOGICAL SCIENCES, 196 (1).
pp. 112-125.