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Kashyap, SS, Johnson, JR ORCID: 0000-0002-8849-0993, McCue, Hannah, Chen, X, Edmonds, MJ, Ayala, M, Graham, ME, Jenn, RC, Barclay, Jeff, Burgoyne, Bob ORCID: 0000-0002-9219-0387 et al (show 1 more authors)
(2014)
Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Human Molecular Genetics, 23 (22).
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Barker, Eleanor, Morgan, Alan ORCID: 0000-0002-0346-1289 and Barclay, Jeff W
(2023)
A Caenorhabditis elegans model of autosomal dominant adult-onset neuronal ceroid lipofuscinosis identifies ethosuximide as a potential therapeutic.
HUMAN MOLECULAR GENETICS, 32 (11).
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Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2015)
Cysteine string protein (CSP) and its role in preventing neurodegeneration.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 40.
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Rupawala, Huzefa, Shah, Keshvi, Davies, Caitlin, Rose, Jamie, Colom-Cadena, Marti, Peng, Xianhui, Granat, Lucy, Aljuhani, Manal, Mizuno, Keiko, Troakes, Claire et al (show 7 more authors)
(2022)
Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease.
BRAIN COMMUNICATIONS, 4 (4).
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Jones, Alistair
(2020)
Developing a multi-organism pipeline for drug-discovery in epilepsy.
PhD thesis, University of Liverpool.
Chen, Xi, McCuef, Hannah V, Wong, Shi Quan, Kashyap, Sudhanva S, Kraemer, Brian C, Barclay, Jeff W, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2015)
Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression.
Molecular Neurodegeneration, 10 (1).
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McCue, Hannah, Chen, Xi, Barclay, Jeff, Morgan, Alan ORCID: 0000-0002-0346-1289 and Burgoyne, Robert D ORCID: 0000-0002-9219-0387
(2015)
Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components.
Scientific reports, 5 (1).
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Morgan, Alan ORCID: 0000-0002-0346-1289
(2020)
Functional analysis of epilepsy‐associated variants in STXBP1/Munc18‐1 using humanized Caenorhabditis elegans.
Epilepsia, 61 (4).
pp. 810-821.
Barker, Eleanor
(2023)
Investigating How ANCL-Causing Mutations Lead to Neurodegeneration.
PhD thesis, University of Liverpool.
Wong, Shi Quan, Pontifex, Matthew G, Phelan, Marie M, Pidathala, Chandra, Kraemer, Brian C, Barclay, Jeff W, Berry, Neil G ORCID: 0000-0003-1928-0738, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2018)
α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy.
Neurobiology of disease, 118.
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Edwards, Mark R, Johnson, James R ORCID: 0000-0002-8849-0993, Rankin, Kimberley, Jenkins, Rosalind E, Maguire, Carl, Morgan, Alan ORCID: 0000-0002-0346-1289, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Barclay, Jeff W
(2012)
PKC-2 Phosphorylation of UNC-18 Ser322 in AFD Neurons Regulates Temperature Dependency of Locomotion.
JOURNAL OF NEUROSCIENCE, 32 (20).
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Patel, Pryank, Prescott, Gerald R, Burgoyne, Robert D ORCID: 0000-0002-9219-0387, Lian, Lu-Yun and Morgan, Alan ORCID: 0000-0002-0346-1289
(2016)
Phosphorylation of Cysteine String Protein Triggers a Major Conformational Switch.
STRUCTURE, 24 (8).
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Campion, Richard, Bloxam, Leanne, Burrow, Kimberley, Brownridge, Philip J, Pentland, Daniel R, Thomas, Patricia, Gourlay, Campbell W, Eyers, Claire E ORCID: 0000-0002-3223-5926, Barclay, Jeff W and Morgan, Alan ORCID: 0000-0002-0346-1289
(2021)
Proteomic analysis of dietary restriction in yeast reveals a role for Hsp26 in replicative lifespan extension.
BIOCHEMICAL JOURNAL, 478 (24).
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Barker, Eleanor, Milburn, Amy, Helassa, Nordine ORCID: 0000-0003-3743-1886, Hammond, Dean, Sanchez-Soriano, Natalia, Morgan, Alan ORCID: 0000-0002-0346-1289 and Barclay, Jeff
(2024)
Proximity labelling reveals effects of disease-causing mutation on the DNAJC5/cysteine string protein α interactome.
The Biochemical journal, 481 (3).
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Afzal, Khoula
(2023)
Rescuing the paralysed phenotype of unc-18 (e81) null mutant C. elegans.
PhD thesis, University of Liverpool.
Bennett, Dominic
(2020)
Rilmenidine is a Calorie Restriction Mimetic that Improves Survival and
Indicators of Healthy Ageing in C. elegans via a Novel IRAS Ortholog,
f13e9.1.
PhD thesis, University of Liverpool.
Barker, Eleanor, Morgan, Alan ORCID: 0000-0002-0346-1289 and Barclay, Jeff W
(2024)
Tissue distribution of cysteine string protein/DNAJC5 in C. elegans analysed by CRISPR/Cas9-mediated tagging of endogenous DNJ-14.
Cell and tissue research.
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Chen, Xi, Barclay, Jeff W, Burgoyne, Robert D ORCID: 0000-0002-9219-0387 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2015)
Using <i>C</i>. <i>elegans</i> to discover therapeutic compounds for ageing-associated neurodegenerative diseases.
CHEMISTRY CENTRAL JOURNAL, 9 (1).
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Chen, Xi, Kraemer, Brian, Barclay, Jeff, Burgoyne, Robert and Morgan, Alan
(2013)
Using Caenorhabditis elegans to fight human neurodegenerative diseases.
PhD thesis, University of Liverpool.
Wong, Shi Quan
(2017)
Using Caenorhabditis elegans to identify succinimide-based neuroprotective compounds and their mechanisms of action.
PhD thesis, University of Liverpool.
Huber, Robert J, Hughes, Stephanie M, Liu, Wenfei, Morgan, Alan ORCID: 0000-0002-0346-1289, Tuxworth, Richard I and Russell, Claire
(2020)
The contribution of multicellular model organisms to neuronal ceroid lipofuscinosis research.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866 (9).
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Kashyap, Sudhanva
dnj-14: a new C. elegans model for neurodegenerative diseases.
PhD thesis, University of Liverpool.
Wong, Shi Quan, Jones, Alistair, Dodd, Steven, Grimes, Douglas ORCID: 0000-0002-1034-6625, Barclay, Jeff W, Marson, Anthony G ORCID: 0000-0002-6861-8806, Cunliffe, Vincent T, Burgoyne, Robert D ORCID: 0000-0002-9219-0387, Sills, Graeme J ORCID: 0000-0002-3389-8713 and Morgan, Alan ORCID: 0000-0002-0346-1289
(2018)
A <i>Caenorhabditis elegans</i> assay of seizure-like activity optimised for identifying antiepileptic drugs and their mechanisms of action.
JOURNAL OF NEUROSCIENCE METHODS, 309.
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Jones, Alistair, Barker-Haliski, Melissa, Ilie, Andrei S, Herd, Murray B, Baxendale, Sarah, Holdsworth, Celia J, Ashton, John-Paul, Placzek, Marysia, Jayasekera, Bodiabaduge AP, Cowie, Christopher JA et al (show 7 more authors)
(2020)
A multiorganism pipeline for antiseizure drug discovery: Identification of chlorothymol as a novel γ-aminobutyric acidergic anticonvulsant.
Epilepsia, 61 (10).
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Campion, Richard
(2021)
The role of small heat shock proteins in longevity and stress resistance in yeast.
Doctor of Philosophy thesis, University of Liverpool.
Jenn, Robert
(2012)
A systematic analysis of human transmembrane E3-RING proteins.
Doctor of Philosophy thesis, University of Liverpool.