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Almutairi, Mubarak, Lister, Adam ORCID: 0000-0003-4085-6367, Zhao, Qing, Line, James
ORCID: 0000-0003-3568-8928, Adair, Kareena
ORCID: 0000-0001-9884-2094, Tailor, Arun, Waddington, James
ORCID: 0000-0003-2641-5055, Clarke, Elsie
ORCID: 0000-0002-5913-0606, Gardner, Joshua
ORCID: 0000-0002-4520-108X, Thomson, Paul
ORCID: 0000-0001-5431-0459 et al (show 10 more authors)
(2023)
Activation of Human CD8+ T Cells with Nitroso Dapsone-Modified HLA-B*13:01-Binding Peptides.
Journal of immunology (Baltimore, Md. : 1950), 210 (8).
pp. 1031-1042.
Hammond, Sean, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Mosedale, Merrie and Naisbitt, Dean J
(2023)
Activation of tolvaptan-responsive T-cell clones with the structurally-related mozavaptan.
Toxicology Letters, 373.
pp. 148-151.
Meng, Xiaoli ORCID: 0000-0002-7774-2075, Earnshaw, Caroline J, Tailor, Arun
ORCID: 0000-0002-9698-3480, Jenkins, Rosalind E, Waddington, James C
ORCID: 0000-0003-2641-5055, Whitaker, Paul, French, Neil S
ORCID: 0000-0002-9376-3482, Naisbitt, Dean J and Park, B Kevin
ORCID: 0000-0001-8384-824X
(2016)
Amoxicillin and Clavulanate Form Chemically and Immunologically Distinct Multiple Haptenic Structures in Patients.
CHEMICAL RESEARCH IN TOXICOLOGY, 29 (10).
pp. 1762-1772.
Amali, Mohammed O, Jenkins, Rosalind E, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Faulkner, Lee, Whitaker, Paul, Peckham, Daniel, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2017)
Assessment of Antipiperacillin IgG Binding to Structurally Related Drug Protein Adducts.
CHEMICAL RESEARCH IN TOXICOLOGY, 30 (12).
pp. 2097-2099.
Waddington, James C ORCID: 0000-0003-2641-5055, Ali, Serat-E
ORCID: 0000-0002-9806-8796, Penman, Sophie L
ORCID: 0000-0001-5326-1675, Whitaker, Paul, Hamlett, Jane, Chadwick, Amy
ORCID: 0000-0002-7399-8655, Naisbitt, Dean J, Park, B Kevin
ORCID: 0000-0001-8384-824X and Meng, Xiaoli
ORCID: 0000-0002-7774-2075
(2020)
Cell Membrane Transporters Facilitate the Accumulation of Hepatocellular Flucloxacillin Protein Adducts: Implication in Flucloxacillin-Induced Liver Injury.
CHEMICAL RESEARCH IN TOXICOLOGY, 33 (12).
pp. 2939-2943.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Lister, Adam, Jenkins, Rosalind E, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Alfirevic, Ana
ORCID: 0000-0002-2801-9817, Douglas, Lisa, Mcloughlin, Rachel, Silva, Edward, Park, B Kevin
ORCID: 0000-0001-8384-824X, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266 et al (show 1 more authors)
(2020)
Characterization of Clozapine-Responsive Human T Cells.
JOURNAL OF IMMUNOLOGY, 205 (9).
2375-+.
Jaruthamsophon, Kanoot, Thomson, Paul J ORCID: 0000-0001-5431-0459, Hammond, Sean, Zhang, Eunice, Alfirevic, Ana
ORCID: 0000-0002-2801-9817, Sukasem, Chonlaphat, Naisbitt, Dean J and Pirmohamed, Munir
ORCID: 0000-0002-7534-7266
(2023)
Characterization of Drug-Specific CD4+T-Cells Reveals Possible Roles of HLA Class II in the Pathogenesis of Carbamazepine Hypersensitivity Reactions.
CHEMICAL RESEARCH IN TOXICOLOGY, 36 (5).
pp. 757-768.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Faulkner, Lee, Jenkins, Roz E, French, Neil S
ORCID: 0000-0002-9376-3482, Copple, Ian M
ORCID: 0000-0003-4101-1913, Antoine, Daniel J, Elmasry, Mohamed, Malik, Hasan, Goldring, Christopher E, Park, Brian Kevin
ORCID: 0000-0001-8384-824X et al (show 2 more authors)
(2017)
Characterization of Drug-Specific Signaling Between Primary Human Hepatocytes and Immune Cells.
TOXICOLOGICAL SCIENCES, 158 (1).
pp. 76-89.
Alhilali, Khetam Ali, Al-Attar, Zaid, Gibson, Andrew, Tailor, Arun ORCID: 0000-0002-9698-3480, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Monshouwer, Mario, Snoeys, Jan, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2019)
Characterization of Healthy Donor-Derived T-Cell Responses Specific to Telaprevir Diastereomers.
TOXICOLOGICAL SCIENCES, 168 (2).
pp. 597-609.
Usui, Toru, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Saide, Katy, Farrell, John
ORCID: 0000-0002-8726-5997, Thomson, Paul
ORCID: 0000-0001-5431-0459, Whitaker, Paul, Watson, John, French, Neil S
ORCID: 0000-0002-9376-3482, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2017)
Characterization of Isoniazid-Specific T-Cell Clones in Patients with anti-Tuberculosis Drug-Related Liver and Skin Injury.
TOXICOLOGICAL SCIENCES, 155 (2).
pp. 420-431.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Jenkins,, Rosalind E, Maggs, James L, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Whitaker, Paul, Peckham, Daniel, Faulkner, Lee, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2015)
Characterization of Peroxidases Expressed in Human AntigenPresenting Cells and Analysis of the Covalent Binding of NitrosoSulfamethoxazole to Myeloperoxidase.
Chemical Research in Toxicology, 28 (1).
pp. 144-154.
Pratoomwun, Jirawat, Thomson, Paul ORCID: 0000-0001-5431-0459, Jaruthamsophon, Kanoot, Tiyasirichokchai, Rawiporn, Jinda, Pimonpan, Rerkpattanapipat, Ticha, Tassaneeyakul, Wichittra, Nakkam, Nontaya, Rerknimitr, Pawinee, Klaewsongkram, Jettanong et al (show 4 more authors)
(2021)
Characterization of T-Cell Responses to SMX and SMX-NO in Co-Trimoxazole Hypersensitivity Patients Expressing HLA-B*13:01.
FRONTIERS IN IMMUNOLOGY, 12.
658593-.
Gardner, Joshua, Ogese, Monday ORCID: 0000-0002-1873-4032, Betts, Catherine J, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266 and Naisbitt, Dean J
(2022)
Characterization of Teicoplanin-Specific T-Cells from Drug Naïve Donors Expressing HLA-A*32:01.
Chemical research in toxicology, 35 (2).
pp. 199-202.
Ariza, Adriana, Fernandez-Santamaria, Ruben, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Salas, Maria, Ogese, Monday O
ORCID: 0000-0002-1873-4032, Tailor, Arun, Bogas, Gador, Torres, Maria Jose and Naisbitt, Dean J
(2020)
Characterization of amoxicillin and clavulanic acid specific T-cell clones from patients with immediate drug hypersensitivity.
ALLERGY, 75 (10).
pp. 2562-2573.
Kim, Seung-Hyun, Saide, Katy, Farrell, John ORCID: 0000-0002-8726-5997, Faulkner, Lee, Tailor, Arun
ORCID: 0000-0002-9698-3480, Ogese, Monday
ORCID: 0000-0002-1873-4032, Daly, Ann K, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2015)
Characterization of amoxicillin‐ and clavulanic acid‐specific T cells in patients with amoxicillin‐clavulanate–induced liver injury.
Hepatology, 62 (3).
pp. 887-899.
Zhao, Qing, Alhilali, Khetam, Alzahrani, Abdulaziz, Almutairi, Mubarak, Amjad, Juwaria, Liu, Hong, Sun, Yonghu, Sun, Lele, Zhang, Huimin, Meng, Xiaoli ORCID: 0000-0002-7774-2075 et al (show 7 more authors)
(2019)
Dapsone‐ and nitroso dapsone‐specific activation of T cells from hypersensitive patients expressing the risk allele HLA‐B*13:01.
Allergy, 74 (8).
pp. 1533-1548.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Lister, Adam, Gardner, Joshua, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Alfirevic, Ana
ORCID: 0000-0002-2801-9817, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2021)
Deciphering Adverse Drug Reactions: In Vitro Priming and Characterization of Vancomycin-Specific T Cells From Healthy Donors Expressing HLA-A*32:01.
TOXICOLOGICAL SCIENCES, 183 (1).
pp. 139-153.
Usui, Toru, Whitaker, Paul, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Watson, John, Antoine, Daniel J, French, Neil S
ORCID: 0000-0002-9376-3482, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2016)
Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury.
CHEMICAL RESEARCH IN TOXICOLOGY, 29 (11).
pp. 1793-1795.
Faulkner, Lee, Gibson, Andrew, Sullivan, Andrew, Tailor, Arun ORCID: 0000-0002-9698-3480, Usui, Toru, Alfirevic, Ana
ORCID: 0000-0002-2801-9817, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266, Naisbitt, Dean J and Park, B Kevin
ORCID: 0000-0001-8384-824X
(2016)
Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
TOXICOLOGICAL SCIENCES, 154 (2).
pp. 416-429.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Watkinson, Joel, Lister, Adam, Faulkner, Lee, Gibson, Andrew, Hillegas, Aimee, Sakatis, Melanie Z, Park, Brian Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2020)
Development of an Improved T-cell Assay to Assess the Intrinsic Immunogenicity of Haptenic Compounds.
Toxicological sciences : an official journal of the Society of Toxicology, 175 (2).
pp. 266-278.
Hammond, Sean, Olsson-Brown, Anna, Grice, Sophie and Naisbitt, Dean J
(2022)
Does immune checkpoint inhibitor therapy increase the frequency of adverse reactions to concomitant medications?
CLINICAL AND EXPERIMENTAL ALLERGY, 52 (5).
pp. 600-603.
Roehmel, Jobst F, Ogese, Monday O ORCID: 0000-0002-1873-4032, Rohrbach, Alexander, Mall, Marcus A and Naisbitt, Dean J
(2021)
Drug allergy to CFTR modulator therapy associated with lumacaftor-specific CD4(+) T lymphocytes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 147 (2).
753-+.
Adair, Kareena ORCID: 0000-0001-9884-2094, Meng, Xiaoli
ORCID: 0000-0002-7774-2075 and Naisbitt, Dean J
(2021)
Drug hapten-specific T-cell activation: Current status and unanswered questions.
PROTEOMICS, 21 (17-18).
e2000267-.
Thomson, Paul J ORCID: 0000-0001-5431-0459, Kafu, Laila, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Snoeys, Jan, De Bondt, An, De Maeyer, Dries, Wils, Hans, Leclercq, Laurent, Vinken, Petra and Naisbitt, Dean J
(2021)
Drug-specific T-cell responses in patients with liver injury following treatment with the BACE inhibitor atabecestat.
ALLERGY, 76 (6).
pp. 1825-1835.
Gibson, Andrew, Faulkner, Lee, Lichtenfels, Maike, Ogese, Monday ORCID: 0000-0002-1873-4032, Al-Attar, Zaid, Alfirevic, Ana
ORCID: 0000-0002-2801-9817, Esser, Philipp R, Martin, Stefan F, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266, Park, B Kevin
ORCID: 0000-0001-8384-824X et al (show 1 more authors)
(2017)
The Effect of Inhibitory Signals on the Priming of Drug Hapten-Specific T Cells That Express Distinct V beta Receptors.
JOURNAL OF IMMUNOLOGY, 199 (4).
pp. 1223-1237.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Jenkins, Rosalind E, Adair, Kareena
ORCID: 0000-0001-9884-2094, Tailor, Arun, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Faulkner, Lee L, Enyindah, Bright O, Schofield, Amy, Diaz-Nieto, R, Ressel, Lorenzo
ORCID: 0000-0002-6614-1223 et al (show 6 more authors)
(2019)
Exosomal transport of hepatocyte-derived drug-modified proteins to the immune system.
Hepatology, 70 (5).
pp. 1732-1749.
Zhao, Qing, Almutairi, Mubarak, Tailor, Arun, Lister, Adam, Harper, Nicolas, Line, James ORCID: 0000-0003-3568-8928, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Pratoomwun, Jirawat, Jaruthamsophon, Kanoot
ORCID: 0000-0003-1563-0024, Sukasem, Chonlaphat et al (show 10 more authors)
(2021)
HLA Class-II. Restricted CD8(+) T Cells Contribute to the Promiscuous Immune Response in Dapsone-Hypersensitive Patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 141 (10).
2412-+.
Tailor, Arun, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Adair, Kareena
ORCID: 0000-0001-9884-2094, Farrell, John
ORCID: 0000-0002-8726-5997, Waddington, James C
ORCID: 0000-0003-2641-5055, Daly, Ann, Pirmohamed, Munir
ORCID: 0000-0002-7534-7266, Dear, Gordon, Park, B Kevin
ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2020)
HLA DaB1*15:01-DQB1*06:02-Restricted Human CD4+T Cells Are Selectively Activated With Amoxicillin-Peptide Adducts.
TOXICOLOGICAL SCIENCES, 178 (1).
pp. 115-126.
Thomson, PJ ORCID: 0000-0001-5431-0459
(2018)
AN INSIGHT INTO THE MECHANISMS OF ABACAVIR INDUCED HYPERSENSITIVITY REACTIONS WITH A VIEW TO DESIGNING SAFER THERAPEUTICS.
PhD thesis, University of Liverpool.
Waddington, James C ORCID: 0000-0003-2641-5055, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Illing, Patricia T, Tailor, Arun, Adair, Kareena
ORCID: 0000-0001-9884-2094, Whitaker, Paul, Hamlett, Jane, Jenkins, Rosalind E, Farrell, John
ORCID: 0000-0002-8726-5997, Berry, Neil
ORCID: 0000-0003-1928-0738 et al (show 3 more authors)
(2020)
Identification of Flucloxacillin-Haptenated HLA-B*57:01 Ligands: Evidence of Antigen Processing and Presentation.
TOXICOLOGICAL SCIENCES, 177 (2).
pp. 454-465.
Gibson, Andrew, Faulkner, Lee, Wood, Sally, Park, B Kevin ORCID: 0000-0001-8384-824X and Naisbitt, Dean J
(2017)
Identification of drug-and drug-metabolite immune responses originating from both naive and memory T cells.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 140 (2).
578-+.
Ali, Serat-E, Waddington, James C, Lister, Adam, Sison-Young, Rowena, Jones, Robert P ORCID: 0000-0001-5608-001X, Rehman, Adeeb H, Goldring, Chris EP, Naisbitt, Dean J and Meng, Xiaoli
ORCID: 0000-0002-7774-2075
(2023)
Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury.
TOXICOLOGICAL SCIENCES, 192 (1).
pp. 106-116.
Waddington, James C ORCID: 0000-0003-2641-5055, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Naisbitt, Dean J and Park, B Kevin
ORCID: 0000-0001-8384-824X
(2018)
Immune drug-induced liver disease and drugs.
Current Opinion in Toxicology, 10.
pp. 46-53.
Naisbitt, Dean J, Olsson-Brown, Anna, Gibson, Andrew, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Ogese, Monday O
ORCID: 0000-0002-1873-4032, Tailor, Arun
ORCID: 0000-0002-9698-3480 and Thomson, Paul
ORCID: 0000-0001-5431-0459
(2020)
Immune dysregulation increases the incidence of delayed-type drug hypersensitivity reactions.
ALLERGY, 75 (4).
pp. 781-797.
Weaver, Richard J, Blomme, Eric A, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Copple, Ian M
ORCID: 0000-0003-4101-1913, Gerets, Helga HJ, Goldring, Christopher E, Guillouzo, Andre, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig et al (show 12 more authors)
(2020)
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
NATURE REVIEWS DRUG DISCOVERY, 19 (2).
pp. 131-148.
Thomson, Paul J ORCID: 0000-0001-5431-0459, Illing, Patricia T, Farrell, John
ORCID: 0000-0002-8726-5997, Alhaidari, Mohammad, Bell, Catherine C, Berry, Neil
ORCID: 0000-0003-1928-0738, O'Neill, Paul M, Purcell, Anthony W, Park, Kevin B and Naisbitt, Dean J
(2020)
Modification of the cyclopropyl moiety of abacavir provides insight into the structure activity relationship between HLA‐B*57:01 binding and T‐cell activation.
ALLERGY, 75 (3).
pp. 636-647.
Ogese, Monday O ORCID: 0000-0002-1873-4032, Ahmed, Shaheda, Alferivic, Ana, Betts, Catherine J, Dickinson, Anne, Faulkner, Lee, French, Neil
ORCID: 0000-0002-9376-3482, Gibson, Andrew, Hirschfield, Gideon M, Kammuller, Michael et al (show 10 more authors)
(2017)
New Approaches to Investigate Drug-Induced Hypersensitivity.
CHEMICAL RESEARCH IN TOXICOLOGY, 30 (1).
pp. 239-259.
Faulkner, Lee, Meng, Xiaoli ORCID: 0000-0002-7774-2075, Naisbitt, Dean J, Spraggs, Colin F and Park, B Kevin
ORCID: 0000-0001-8384-824X
(2016)
No Evidence for Drug-Specific Activation of Circulating T Cells from Patients with HLA-DRB1*07:01-Restricted Lapatinib-Induced Liver Injury.
CHEMICAL RESEARCH IN TOXICOLOGY, 29 (12).
pp. 2111-2113.
Thomson, Paul ORCID: 0000-0001-5431-0459, Hammond, Sean and Naisbitt, Dean J
(2022)
Pathology of drug hypersensitivity reactions and mechanisms of immune tolerance.
CLINICAL AND EXPERIMENTAL ALLERGY, 52 (12).
pp. 1379-1390.
Yaseen, Fiazia S, Saide, Katy, Kim, Seung-Hyun, Monshi, Manal, Tailor, Arun ORCID: 0000-0002-9698-3480, Wood, Sally, Meng, Xiaoli
ORCID: 0000-0002-7774-2075, Jenkins, Rosalind, Faulkner, Lee, Daly, Ann K et al (show 3 more authors)
(2015)
Promiscuous T-cell responses to drugs and drug-haptens.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 136 (2).
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Setiabudi, Wega ORCID: 0000-0003-2510-0318, Hungerford, Daniel
ORCID: 0000-0002-9770-0163, Subramaniam, Krishanthi
ORCID: 0000-0002-1734-9351, Vaselli, Natasha Marcella, Shaw, Victoria E
ORCID: 0000-0002-0429-0186, Wilton, Moon
ORCID: 0000-0003-4052-7918, Vivancos, Roberto, Aston, Stephen
ORCID: 0000-0002-0701-8364, Platt, Gareth
ORCID: 0000-0002-6687-0012, Moitt, Tracy
ORCID: 0000-0002-5579-996X et al (show 12 more authors)
(2021)
Prospective observational study of SARS-CoV-2 infection, transmission and immunity in a cohort of households in Liverpool City Region, UK (COVID-LIV): a study protocol.
BMJ Open, 11 (3).
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Hammond, Sean, Gibson, Andrew, Jaruthamsophon, Kanoot ORCID: 0000-0003-1563-0024, Roth, Sharin, Mosedale, Merrie and Naisbitt, Dean J
(2021)
Shedding Light on Drug-Induced Liver Injury: Activation of T Cells From Drug Naive Human Donors With Tolvaptan and a Hydroxybutyric Acid Metabolite.
TOXICOLOGICAL SCIENCES, 179 (1).
pp. 95-107.
Ogbe, Ane, Kronsteiner, Barbara, Skelly, Donal T, Pace, Matthew, Brown, Anthony, Adland, Emily, Adair, Kareena ORCID: 0000-0001-9884-2094, Akhter, Hossain Delowar, Ali, Mohammad, Ali, Serat-E
ORCID: 0000-0002-9806-8796 et al (show 70 more authors)
(2021)
T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses.
NATURE COMMUNICATIONS, 12 (1).
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Gibson, Andrew, Hammond, Sean, Jaruthamsophon, Kanoot ORCID: 0000-0003-1563-0024, Roth, Sharin, Mosedale, Merrie and Naisbitt, Dean J
(2020)
Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury.
CHEMICAL RESEARCH IN TOXICOLOGY, 33 (11).
pp. 2745-2748.
Kim, Seung-Hyun and Naisbitt, Dean J
(2016)
Update on Advances in Research on Idiosyncratic Drug-Induced Liver Injury.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 8 (1).
pp. 3-11.
Thomson, Paul, Hammond, Sean, Meng, Xiaoli ORCID: 0000-0002-7774-2075 and Naisbitt, Dean J
(2023)
What’s been Hapten-ing over the last 88 years?
Medicinal Chemistry Research.