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Ranganath, Lakshminarayan R ORCID: 0000-0002-4205-2269, Milan, Anna M, Hughes, Andrew T, Khedr, Milad, Norman, Brendan P ORCID: 0000-0001-9293-4852, Alsbou, Mohammed, Imrich, Richard, Gornall, Matthew, Sireau, Nicolas, Gallagher, James A ORCID: 0000-0002-0852-279X et al (show 1 more authors) and Jackson, Richard (2022) Comparing nitisinone 2 mg and 10 mg in the treatment of alkaptonuria-An approach using statistical modelling. JIMD reports, 63 (1). pp. 80-92.

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Ranganath, Lakshminarayan R, Milan, Anna M, Hughes, Andrew T, Davison, Andrew S ORCID: 0000-0001-5501-4475, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P ORCID: 0000-0001-9293-4852, Bou-Gharios, George et al (show 1 more authors) and Gallagher, James A (2022) Comparing the Phenylalanine/Tyrosine Pathway and Related Factors between Keratopathy and No-Keratopathy Groups as Well as between Genders in Alkaptonuria during Nitisinone Treatment. METABOLITES, 12 (8). 772-.

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Norman, Brendan P ORCID: 0000-0001-9293-4852, Davison, Andrew S ORCID: 0000-0001-5501-4475, Hickton, Bryony, Ross, Gordon A, Milan, Anna M ORCID: 0000-0002-0452-2338, Hughes, Andrew T, Wilson, Peter JM, Sutherland, Hazel, Hughes, Juliette H ORCID: 0000-0001-6155-4136, Roberts, Norman B et al (show 3 more authors) , Bou-Gharios, George, Gallagher, James A and Ranganath, Lakshminarayan R (2022) Comprehensive Biotransformation Analysis of Phenylalanine-Tyrosine Metabolism Reveals Alternative Routes of Metabolite Clearance in Nitisinone-Treated Alkaptonuria. METABOLITES, 12 (10). 927-.

Norman, Brendan P ORCID: 0000-0001-9293-4852, Davison, Andrew S ORCID: 0000-0001-5501-4475, Ross, Gordon A, Milan, Anna M ORCID: 0000-0002-0452-2338, Hughes, Andrew T, Sutherland, Hazel, Jarvis, Jonathan C, Roberts, Norman B, Gallagher, James A ORCID: 0000-0002-0852-279X and Ranganath, Lakshminarayan R (2019) A Comprehensive LC-QTOF-MS Metabolic Phenotyping Strategy: Application to Alkaptonuria. Clinical chemistry, 65 (4). pp. 530-539.

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Hughes, Juliette H ORCID: 0000-0001-6155-4136, Liu, Ke, Plagge, Antonius ORCID: 0000-0001-6592-1343, Wilson, Peter JM, Sutherland, Hazel, Norman, Brendan P ORCID: 0000-0001-9293-4852, Hughes, Andrew T, Keenan, Craig M ORCID: 0000-0002-8782-8016, Milan, Anna M ORCID: 0000-0002-0452-2338, Sakai, Takao ORCID: 0000-0002-7375-5450 et al (show 3 more authors) , Ranganath, Lakshminarayan R, Gallagher, James A and Bou-Gharios, George (2019) Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human Molecular Genetics, 28 (23). pp. 3928-3939.

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Hughes, Juliette H ORCID: 0000-0001-6155-4136, Liu, Ke, Plagge, Antonius ORCID: 0000-0001-6592-1343, Wilson, Peter JM, Sutherland, Hazel, Norman, Brendan P, Hughes, Andrew T, Keenan, Craig M, Milan, Anna M, Sakai, Takao ORCID: 0000-0002-7375-5450 et al (show 3 more authors) , Ranganath, Lakshminarayan R, Gallagher, James A and Bou-Gharios, George ORCID: 0000-0002-9563-9418 (2019) Conditional targeting in mice reveals that hepatic homogentisate 1,2-dioxygenase activity is essential in reducing circulating homogentisic acid and for effective therapy in the genetic disease alkaptonuria. Human molecular genetics.

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Ranganath, Lakshminarayan R, Psarelli, Eftychia Eirini ORCID: 0000-0002-3102-0288, Arnoux, Jean-Baptiste, Braconi, Daniela, Briggs, Michael, Broijersen, Anders, Loftus, Nadia, Bygott, Helen, Cox, Trevor F, Davison, Andrew S ORCID: 0000-0001-5501-4475 et al (show 39 more authors) , Dillon, Jane P ORCID: 0000-0002-7055-5664, Fisher, Michael, FitzGerald, Richard, Genovese, Federica, Glasova, Helena, Hall, Anthony K, Hughes, Andrew T, Hughes, Juliette H ORCID: 0000-0001-6155-4136, Imrich, Richard, Jarvis, Jonathan C, Khedr, Milad, Laan, Dinny, Sang, Kim-Hanh Le Quan, Luangrath, Emily, Lukacova, Olga, Milan, Anna M, Mistry, Alpesh, Mlynarikova, Vanda, Norman, Brendan P ORCID: 0000-0001-9293-4852, Olsson, Birgitta, Rhodes, Nicholas P ORCID: 0000-0002-5173-7032, Rovensky, Jozef, Rudebeck, Mattias, Santucci, Annalisa, Shweihdi, Ella, Scott, Ciaran, Sedlakova, Jana, Sireau, Nicolas, Stancik, Roman, Szamosi, Johan, Taylor, Sophie, van Kan, Christa, Vinjamuri, Sobhan, Vrtikova, Eva, Webb, Chris, West, Elizabeth, Zanova, Elizabeth, Zatkova, Andrea and Gallagher, James A ORCID: 0000-0002-0852-279X (2020) Efficacy and safety of once-daily nitisinone for patients with alkaptonuria (SONIA 2): an international, multicentre, open-label, randomised controlled trial. The Lancet Diabetes and Endocrinology, 8 (9). pp. 762-772.

Davison, Andrew S ORCID: 0000-0001-5501-4475, Norman, Brendan P ORCID: 0000-0001-9293-4852, Ross, Gordon A, Hughes, Andrew T, Khedr, Milad ORCID: 0000-0002-4998-2397, Milan, Anna M ORCID: 0000-0002-0452-2338, Gallagher, James A and Ranganath, Lakshminarayan R (2019) Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC-QTOF-MS. JIMD reports, 48 (1). pp. 67-74.

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Ranganath, Lakshminarayan R, Milan, Anna M ORCID: 0000-0002-0452-2338, Hughes, Andrew T, Khedr, Milad ORCID: 0000-0002-4998-2397, Davison, Andrew S ORCID: 0000-0001-5501-4475, Shweihdi, Ella, Norman, Brendan P ORCID: 0000-0001-9293-4852, Hughes, Juliette H ORCID: 0000-0001-6155-4136, Bygott, Helen, Luangrath, Emily et al (show 20 more authors) , Fitzgerald, Richard, Psarelli, Eftychia E ORCID: 0000-0002-3102-0288, van Kan, Christa, Laan, Dinny, Olsson, Birgitta, Rudebeck, Mattias, Mankowitz, Louise, Sireau, Nicolas, Arnoux, Jean-Baptiste, Sang, Kim-Hanh Le Quan, Jarvis, Jonathan C, Genovese, Federica, Braconi, Daniela, Santucci, Annalisa, Zatkova, Andrea, Glasova, Helena, Stancik, Roman, Imrich, Richard, Rhodes, Nicholas P ORCID: 0000-0002-5173-7032 and Gallagher, James A ORCID: 0000-0002-0852-279X (2020) Homogentisic acid is not only eliminated by glomerular filtration and tubular secretion but also produced in the kidney in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43 (4). pp. 737-747.

Davison, Andrew S ORCID: 0000-0001-5501-4475, Norman, Brendan P ORCID: 0000-0001-9293-4852, Sutherland, Hazel, Milan, Anna M, Gallagher, James A ORCID: 0000-0002-0852-279X, Jarvis, Jonathan C and Ranganath, Lakshminarayan R (2022) Impact of Nitisinone on the Cerebrospinal Fluid Metabolome of a Murine Model of Alkaptonuria. METABOLITES, 12 (6). 477-.

Ranganath, Lakshminarayan, Khedr, Milad, Milan, Anna M, Davison, Andrew S, Norman, Brendan P, Janssen, Mirian CH, Lock, Edward, Bou‐Gharios, George and Gallagher, James A (2023) Increased prevalence of Parkinson's disease in alkaptonuria. JIMD Reports, 64 (4). pp. 282-292.

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Norman, Brendan P ORCID: 0000-0001-9293-4852, Davison, Andrew S ORCID: 0000-0001-5501-4475, Hughes, Juliette H ORCID: 0000-0001-6155-4136, Sutherland, Hazel, Wilson, Peter JM, Berry, Neil G ORCID: 0000-0003-1928-0738, Hughes, Andrew T, Milan, Anna M, Jarvis, Jonathan C, Roberts, Norman B et al (show 3 more authors) , Ranganath, Lakshminarayan R, Bou-Gharios, George and Gallagher, James A ORCID: 0000-0002-0852-279X (2022) Metabolomic studies in the inborn error of metabolism alkaptonuria reveal new biotransformations in tyrosine metabolism. GENES & DISEASES, 9 (4). pp. 1129-1142.

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Khedr, Milad ORCID: 0000-0002-4998-2397, Cooper, Maggie S, Hughes, Andrew T, Milan, Anna M ORCID: 0000-0002-0452-2338, Davison, Andrew S ORCID: 0000-0001-5501-4475, Norman, Brendan P ORCID: 0000-0001-9293-4852, Sutherland, Hazel, Jarvis, Jonathan C, Fitzgerald, Richard, Markinson, Louise et al (show 5 more authors) , Psarelli, Eftychia-Eirini ORCID: 0000-0002-3102-0288, Ghane, Parisa, Deutz, Nicolaas EP, Gallagher, James A ORCID: 0000-0002-0852-279X and Ranganath, Lakshminarayan R (2020) Nitisinone causes acquired tyrosinosis in alkaptonuria. JOURNAL OF INHERITED METABOLIC DISEASE, 43 (5). pp. 1014-1023.

Ranganath, Lakshminarayan R, Norman, Brendan P ORCID: 0000-0001-9293-4852 and Gallagher, James A (2019) Ochronotic pigmentation is caused by homogentisic acid and is the key event in alkaptonuria leading to the destructive consequences of the disease-A review. JOURNAL OF INHERITED METABOLIC DISEASE, 42 (5). pp. 776-792.

Chow, Wing Ying, Norman, Brendan P ORCID: 0000-0001-9293-4852, Roberts, Norman B, Ranganath, Lakshminarayan R, Teutloff, Christian, Bittl, Robert, Duer, Melinda J, Gallagher, James A ORCID: 0000-0002-0852-279X and Oschkinat, Hartmut (2020) Pigmentation Chemistry and Radical-Based Collagen Degradation in Alkaptonuria and Osteoarthritic Cartilage. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 59 (29). pp. 11937-11942.

Chow, Wing Ying ORCID: 0000-0003-0719-5958, Norman, Brendan P ORCID: 0000-0001-9293-4852, Roberts, Norman B, Ranganath, Lakshminarayan R ORCID: 0000-0002-4205-2269, Teutloff, Christian ORCID: 0000-0001-6949-1985, Bittl, Robert ORCID: 0000-0003-4103-3768, Duer, Melinda J ORCID: 0000-0002-9196-5072, Gallagher, James A ORCID: 0000-0002-0852-279X and Oschkinat, Hartmut ORCID: 0000-0002-4384-9544 (2020) Pigmentierungschemie und radikalbasierter Kollagenabbau bei Alkaptonurie und Arthrose. Angewandte Chemie, 132 (29). pp. 12035-12040.

Loh, Hui-Yi, Norman, Brendan P ORCID: 0000-0001-9293-4852, Lai, Kok-Song, Cheng, Wan-Hee, Nik Abd Rahman, Nik Mohd Afizan, Mohamed Alitheen, Noorjahan Banu and Osman, Mohd Azuraidi (2023) Post-Transcriptional Regulatory Crosstalk between MicroRNAs and Canonical TGF-β/BMP Signalling Cascades on Osteoblast Lineage: A Comprehensive Review. International journal of molecular sciences, 24 (7). p. 6423.

Loh, Hui-Yi, Norman, Brendan P ORCID: 0000-0001-9293-4852, Lai, Kok-Song, Abd Rahman, Nik Mohd Afizan Nik, Alitheen, Noorjahan Banu Mohamed and Osman, Mohd Azuraidi (2019) The Regulatory Role of MicroRNAs in Breast Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20 (19). E4940-.

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Ranganath, Lakshminarayan R, Hughes, Andrew T, Davison, Andrew S ORCID: 0000-0001-5501-4475, Khedr, Milad, Imrich, Richard, Rudebeck, Mattias, Olsson, Birgitta, Norman, Brendan P ORCID: 0000-0001-9293-4852, Bou-Gharios, George, Gallagher, James A et al (show 1 more authors) and Milan, Anna M ORCID: 0000-0002-0452-2338 (2022) Revisiting Quantification of Phenylalanine/Tyrosine Flux in the Ochronotic Pathway during Long-Term Nitisinone Treatment of Alkaptonuria. METABOLITES, 12 (10). 920-.

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Norman, Brendan P ORCID: 0000-0001-9293-4852, Davison, Andrew S ORCID: 0000-0001-5501-4475, Hughes, Juliette H ORCID: 0000-0001-6155-4136, Sutherland, Hazel, Wilson, Peter J, Berry, Neil G, Hughes, Andrew T, Milan, Anna M, Jarvis, Jonathan C, Roberts, Norman B et al (show 3 more authors) , Ranganath, Lakshminarayan R, Bou-Gharios, George and Gallagher, James A (2020) Studies in alkaptonuria reveal new roles beyond drug clearance for phase I and II biotransformations in tyrosine metabolism. biorxiv. (Unpublished)