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Liatsikos, Konstantinos, Hyder-Wright, Angela, Pojar, Sherin, Chen, Tao ORCID: 0000-0002-5489-6450, Wang, Duolao, Davies, Kelly, Myerscough, Christopher, Reine, Jesus, Robinson, Ryan E, Urban, Britta et al (show 12 more authors) , Mitsi, Elena, Solorzano, Carla, Gordon, Stephen B, Quinn, Angela, Pan, Kaijie, Anderson, Annaliesa S, Theilacker, Christian, Begier, Elizabeth, Gessner, Bradford D, Collins, Andrea, Ferreira, Daniela M and PNEUMO 2 study group, (2022) Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2). BMJ Open, 12 (7). e062109-e062109.