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Bastard, Paul, Gervais, Adrian ORCID: 0000-0002-1083-5787, Le Voyer, Tom, Rosain, Jérémie, Philippot, Quentin, Manry, Jérémy, Michailidis, Eleftherios ORCID: 0000-0002-9907-4346, Hoffmann, Hans-Heinrich, Eto, Shohei, Garcia-Prat, Marina ORCID: 0000-0001-5387-1908 et al (show 191 more authors) , Bizien, Lucy, Parra-Martínez, Alba, Yang, Rui, Haljasmägi, Liis, Migaud, Mélanie, Särekannu, Karita, Maslovskaja, Julia, de Prost, Nicolas, Tandjaoui-Lambiotte, Yacine, Luyt, Charles-Edouard, Amador-Borrero, Blanca, Gaudet, Alexandre, Poissy, Julien, Morel, Pascal ORCID: 0000-0002-8916-7717, Richard, Pascale, Cognasse, Fabrice, Troya, Jesus, Trouillet-Assant, Sophie, Belot, Alexandre ORCID: 0000-0003-4902-5332, Saker, Kahina, Garçon, Pierre, Rivière, Jacques G, Lagier, Jean-Christophe ORCID: 0000-0003-0771-8245, Gentile, Stéphanie, Rosen, Lindsey B, Shaw, Elana ORCID: 0000-0001-9265-8026, Morio, Tomohiro, Tanaka, Junko, Dalmau, David, Tharaux, Pierre-Louis ORCID: 0000-0002-6062-5905, Sene, Damien, Stepanian, Alain, Megarbane, Bruno ORCID: 0000-0002-2522-2764, Triantafyllia, Vasiliki, Fekkar, Arnaud, Heath, James R, Franco, José Luis, Anaya, Juan-Manuel, Solé-Violán, Jordi, Imberti, Luisa ORCID: 0000-0002-2075-8391, Biondi, Andrea ORCID: 0000-0002-6757-6173, Bonfanti, Paolo ORCID: 0000-0001-7289-8823, Castagnoli, Riccardo ORCID: 0000-0003-0029-9383, Delmonte, Ottavia M, Zhang, Yu, Snow, Andrew L, Holland, Steven M, Biggs, Catherine, Moncada-Vélez, Marcela, Arias, Andrés Augusto, Lorenzo, Lazaro, Boucherit, Soraya, Coulibaly, Boubacar, Anglicheau, Dany, Planas, Anna M, Haerynck, Filomeen, Duvlis, Sotirija, Nussbaum, Robert L, Ozcelik, Tayfun, Keles, Sevgi, Bousfiha, Ahmed A, El Bakkouri, Jalila, Ramirez-Santana, Carolina, Paul, Stéphane, Pan-Hammarström, Qiang, Hammarström, Lennart, Dupont, Annabelle, Kurolap, Alina ORCID: 0000-0002-7005-3621, Metz, Christine N, Aiuti, Alessandro, Casari, Giorgio, Lampasona, Vito, Ciceri, Fabio, Barreiros, Lucila A, Dominguez-Garrido, Elena, Vidigal, Mateus, Zatz, Mayana, van de Beek, Diederik, Sahanic, Sabina, Tancevski, Ivan, Stepanovskyy, Yurii, Boyarchuk, Oksana, Nukui, Yoko, Tsumura, Miyuki, Vidaur, Loreto, Tangye, Stuart G, Burrel, Sonia, Duffy, Darragh, Quintana-Murci, Lluis, Klocperk, Adam, Kann, Nelli Y, Shcherbina, Anna, Lau, Yu-Lung, Leung, Daniel, Coulongeat, Matthieu, Marlet, Julien, Koning, Rutger, Reyes, Luis Felipe, Chauvineau-Grenier, Angélique, Venet, Fabienne, Monneret, Guillaume, Nussenzweig, Michel C, Arrestier, Romain, Boudhabhay, Idris, Baris-Feldman, Hagit, Hagin, David, Wauters, Joost, Meyts, Isabelle, Dyer, Adam H ORCID: 0000-0003-1356-510X, Kennelly, Sean P, Bourke, Nollaig M, Halwani, Rabih, Sharif-Askari, Narjes Saheb, Dorgham, Karim, Sallette, Jérome, Sedkaoui, Souad Mehlal, AlKhater, Suzan, Rigo-Bonnin, Raúl, Morandeira, Francisco, Roussel, Lucie, Vinh, Donald C, Ostrowski, Sisse Rye, Condino-Neto, Antonio, Prando, Carolina, Bonradenko, Anastasiia, Spaan, András N, Gilardin, Laurent, Fellay, Jacques, Lyonnet, Stanislas, Bilguvar, Kaya, Lifton, Richard P, Mane, Shrikant, HGID Lab, , COVID Clinicians, , COVID-STORM Clinicians, , NIAID Immune Response to COVID Group, , NH-COVAIR Study Group, , Danish CHGE, , Danish Blood Donor Study, , St. James's Hospital, , SARS CoV2 Interest group, , French COVID Cohort Study Group, , Imagine COVID-Group, , Milieu Intérieur Consortium, , CoV-Contact Cohort, , Amsterdam UMC Covid-19, , Biobank Investigators, , COVID Human Genetic Effort, , CONSTANCES cohort, , 3C-Dijon Study, , Cerba Health-Care, , Etablissement du Sang study group, , Anderson, Mark S, Boisson, Bertrand ORCID: 0000-0001-5240-3555, Béziat, Vivien ORCID: 0000-0002-4020-824X, Zhang, Shen-Ying, Vandreakos, Evangelos, Hermine, Olivier, Pujol, Aurora, Peterson, Pärt, Mogensen, Trine H, Rowen, Lee, Mond, James, Debette, Stéphanie, de Lamballerie, Xavier, Duval, Xavier, Mentré, France, Zins, Marie, Soler-Palacin, Pere, Colobran, Roger, Gorochov, Guy ORCID: 0000-0003-2097-9677, Solanich, Xavier, Susen, Sophie, Martinez-Picado, Javier, Raoult, Didier ORCID: 0000-0002-0633-5974, Vasse, Marc, Gregersen, Peter K, Piemonti, Lorenzo, Rodríguez-Gallego, Carlos, Notarangelo, Luigi D, Su, Helen C, Kisand, Kai, Okada, Satoshi, Puel, Anne ORCID: 0000-0003-2603-0323, Jouanguy, Emmanuelle, Rice, Charles M, Tiberghien, Pierre ORCID: 0000-0002-9310-8322, Zhang, Qian, Cobat, Aurélie, Abel, Laurent and Casanova, Jean-Laurent (2021) Autoantibodies neutralizing type I IFNs are present in <b>~</b>4% of uninfected individuals over 70 years old and account for <b>~</b>20% of COVID-19 deaths. Science immunology, 6 (62). eabl4340-.