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Noor, Nurulamin M ORCID: 0000-0003-3426-6408, Lee, James C ORCID: 0000-0001-5711-9385, Bond, Simon ORCID: 0000-0003-2528-1040, Dowling, Francis, Brezina, Biljana, Patel, Kamal V, Ahmad, Tariq, Banim, Paul J, Berrill, James W, Cooney, Rachel et al (show 33 more authors) , De La Revilla Negro, Juan, de Silva, Shanika, Din, Shahida, Durai, Dharmaraj, Gordon, John N, Irving, Peter M, Johnson, Matthew, Kent, Alexandra J, Kok, Klaartje B, Moran, Gordon W ORCID: 0000-0002-8906-6908, Mowat, Craig ORCID: 0000-0002-5021-415X, Patel, Pritash, Probert, Chris S ORCID: 0000-0003-0477-6714, Raine, Tim ORCID: 0000-0002-5855-9873, Saich, Rebecca, Seward, Abigail, Sharpstone, Dan, Smith, Melissa A, Subramanian, Sreedhar, Upponi, Sara S, Wiles, Alan, Williams, Horace RT, van den Brink, Gijs R, Vermeire, Séverine, Jairath, Vipul, D'Haens, Geert R, McKinney, Eoin F, Lyons, Paul A, Lindsay, James O, Kennedy, Nicholas A, Smith, Kenneth GC, Parkes, Miles and PROFILE Study Group, (2024) A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial. The lancet. Gastroenterology & hepatology. S2468-1253(24)00034-7-.