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Williamson, P ORCID: 0000-0001-9802-6636, Altman, DG, Bagley, H, Barnes, KL ORCID: 0000-0002-8517-8996, Blazeby, JM, Brookes, ST, Clarke, M, Gargon, E, Gorst, S ORCID: 0000-0002-7818-9646, Harman, N ORCID: 0000-0001-6958-6466 et al (show 6 more authors) , Kirkham, JJ ORCID: 0000-0003-2579-9325, McNair, A, Prinsen, CAC, Schmitt, J, Terwee, CB and Young, B ORCID: 0000-0001-6041-9901 (2017) The COMET Handbook: version 1.0. Trials, 18 (Suppl ).