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Number of items: 28.


Hong, W David, Benayoud, Farid, Nixon, Gemma L, Ford, Louise, Johnston, Kelly L, Clare, Rachel H, Cassidy, Andrew, Cook, Darren AN, Siu, Amy, Shiotani, Motohiro
et al (show 24 more authors) (2019) AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 116 (4). pp. 1414-1419.


Turner, Joseph D, Sharma, Raman, Al Jayoussi, Ghaith, Tyrer, Hayley E, Gamble, Joanne ORCID: 0000-0001-7302-3412, Hayward, Laura, Priestley, Richard S, Murphy, Emma A, Davies, Jill, Waterhouse, David
et al (show 10 more authors) (2017) Albendazole and antibiotics synergize to deliver short-course anti-<i>Wolbachia</i> curative treatments in preclinical models of filariasis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 114 (45). E9712-E9721.


Johnston, Kelly L, Hong, W David, Turner, Joseph D, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A and Taylor, Mark J
(2021) Anti-Wolbachia drugs for filariasis. TRENDS IN PARASITOLOGY, 37 (12). pp. 1068-1081.


Camarda, Grazia, Jirawatcharadech, Piyaporn, Priestley, Richard S, Saif, Ahmed, March, Sandra, Wong, Michael HL, Leung, Suet, Miller, Alex B, Baker, David A, Alano, Pietro
et al (show 5 more authors) (2019) Antimalarial activity of primaquine operates via a two-step biochemical relay. NATURE COMMUNICATIONS, 10 (1). 3226-.


Ismail, Hanafy M, Barton, Victoria E, Panchana, Matthew, Charoensutthivarakul, Sitthivut, Biagini, Giancarlo A ORCID: 0000-0001-6356-6595, Ward, Stephen A and O'Neill, Paul M ORCID: 0000-0003-4338-0317
(2016) A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile. Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 128 (22). pp. 6511-6515.


Lisauskaitė, Monika ORCID: 0009-0000-1364-5439, Nixon, Gemma L ORCID: 0000-0002-9730-0960, Woodley, Christopher M ORCID: 0000-0003-1311-4288, Berry, Neil G ORCID: 0000-0003-1928-0738, Coninckx, Andy ORCID: 0000-0001-9821-2746, Qie, L Charlie ORCID: 0009-0002-6325-7447, Leung, Suet C, Taramelli, Donatella ORCID: 0000-0001-5108-4492, Basilico, Nicoletta ORCID: 0000-0001-9030-1066, Parapini, Silvia ORCID: 0000-0003-2079-8892
et al (show 5 more authors) (2024) Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>. RSC chemical biology, 5 (1). pp. 19-29.


McGillan, Paul, Berry, Neil G ORCID: 0000-0003-1928-0738, Nixon, Gemma L, Leung, Suet C, Webborn, Peter JH, Wenlock, Mark C, Kavanagh, Stefan, Cassidy, Andrew, Clare, Rachel H, Cook, Darren A
et al (show 6 more authors) (2021) Development of Pyrazolopyrimidine Anti-Wolbachia Agents for the Treatment of Filariasis. ACS Medicinal Chemistry Letters, 12 (9). pp. 1421-1426.


Rajoli, Rajith KR ORCID: 0000-0002-6015-5712, Pertinez, Henry, Arshad, Usman ORCID: 0000-0003-1586-1885, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 13 more authors) (2021) Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 87 (4). pp. 2078-2088.


Rajoli, Rajith Kr ORCID: 0000-0002-6015-5712, Pertinez, Henry, Arshad, Usman ORCID: 0000-0003-1586-1885, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 13 more authors) (2020) Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis. medRxiv : the preprint server for health sciences.


Woodley, Christopher M, Nixon, Gemma L, Basilico, Nicoletta, Parapini, Silvia, Hong, Weiqian David, Ward, Stephen A, Biagini, Giancarlo A, Leung, Suet C, Taramelli, Donatella, Onuma, Keiko
et al (show 2 more authors) (2021) Enantioselective Synthesis and Profiling of Potent, Nonlinear Analogues of Antimalarial Tetraoxanes E209 and N205. ACS MEDICINAL CHEMISTRY LETTERS, 12 (7). pp. 1077-1085.


Copple, Ian M ORCID: 0000-0003-4101-1913, Mercer, Amy E ORCID: 0000-0002-7399-8655, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael HL, Chadwick, James, Bringela, Andreia D, Cristiano, Maria LS, van de Water, Bob
et al (show 3 more authors) (2012) Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials. MOLECULAR MEDICINE, 18 (7). pp. 1045-1055.


Mansoor, Rashid, Commons, Robert J, Douglas, Nicholas M, Abuaku, Benjamin, Achan, Jane, Adam, Ishag, Adjei, George O, Adjuik, Martin, Alemayehu, Bereket H, Allan, Richard
et al (show 138 more authors) (2022) Haematological consequences of acute uncomplicated falciparum malaria: a WorldWide Antimalarial Resistance Network pooled analysis of individual patient data. BMC MEDICINE, 20 (1). 85-.


Johnston, Kelly L, Cook, Darren AN, Berry, Neil G ORCID: 0000-0003-1928-0738, Hong, W David, Clare, Rachel H, Goddard, Megan, Ford, Louise, Nixon, Gemma L, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A
et al (show 1 more authors) (2017) Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library. SCIENCE ADVANCES, 3 (09). eaao1551-.


Jeffreys, Laura N, Ardrey, Alison, Hafiz, Taghreed A, Dyer, Lauri-Anne, Warman, Ashley J, Mosallam, Nada, Nixon, Gemma L, Fisher, Nicholas E, Hong, W David, Leung, Suet C
et al (show 11 more authors) (2023) Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome bd and Chemical Validation of Combination Strategies for Respiratory Inhibitors against Mycobacterium tuberculosis. ACS INFECTIOUS DISEASES, 9 (2). pp. 221-238.


Clare, Rachel H, Bardelle, Catherine, Harper, Paul, Hong, W David, Borjesson, Ulf, Johnston, Kelly L, Collier, Matthew, Myhill, Laura, Cassidy, Andrew, Plant, Darren
et al (show 21 more authors) (2019) Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides. NATURE COMMUNICATIONS, 10 (1). 11-.


Requena-Mendez, Ana, Davies, Geraint ORCID: 0000-0002-3819-490X, Waterhouse, David, Ardrey, Alison, Jave, Oswaldo, Llanet Lopez-Romero, Sonia, Ward, Stephen A and Moore, David AJ
(2019) Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 74 (2). pp. 416-424.


O' Neill, Paul M, Sabbani, Sunil, Nixon, Gemma L, Schnaderbeck, Matthew, Roberts, Natalie L, Shore, Emma R, Riley, Christopher, Murphy, Ben, McGillan, Paul, Ward, Stephen A
et al (show 2 more authors) (2016) Optimisation of the synthesis of second generation 1,2,4,5 tetraoxane antimalarials. TETRAHEDRON, 72 (40). pp. 6118-6126.


Arshad, Usman ORCID: 0000-0003-1586-1885, Pertinez, Henry, Box, Helen, Tatham, Lee ORCID: 0000-0001-9448-8876, Rajoli, Rajith Kr ORCID: 0000-0002-6015-5712, Curley, Paul ORCID: 0000-0003-4596-2708, Neary, Megan ORCID: 0000-0002-4960-2139, Sharp, Joanne, Liptrott, Neill J ORCID: 0000-0002-5980-8966, Valentijn, Anthony
et al (show 12 more authors) (2020) Prioritisation of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics. Clinical pharmacology and therapeutics, 108 (4). pp. 775-790.


Jeffreys, Laura N, Pennington, Shaun H, Duggan, Jack, Caygill, Claire H, Lopeman, Rose C, Breen, Alastair F, Jinks, Jessica B, Ardrey, Alison, Donnellan, Samantha, Patterson, Edward I
et al (show 7 more authors) (2022) Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 59 (3). 106542-.


Aljayyoussi, Ghaith, Tyrer, Hayley E, Ford, Louise, Sjoberg, Hanna, Pionnier, Nicolas, Waterhouse, David, Davies, Jill, Gamble, Joanne ORCID: 0000-0001-7302-3412, Metugene, Haelly, Cook, Darren AN
et al (show 12 more authors) (2017) Short-Course, High-Dose Rifampicin Achieves <i>Wolbachia</i> Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. SCIENTIFIC REPORTS, 7 (1). 210-.


O' Neill, Paul M, Stocks, Paul A, Sabbani, Sunil, Roberts, Natalie L, Amewu, Richard K ORCID: 0000-0002-4676-436X, Shore, Emma R, Aljayyoussi, Ghaith, Angulo-Barturen, Inigo, Belen, Maria, Jimenez-Diaz,
et al (show 12 more authors) (2018) Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria. BIOORGANIC & MEDICINAL CHEMISTRY, 26 (11). pp. 2996-3005.


Jiang, Zhengyun, Hong, W David, Cui, Xiping, Gao, Hongcan, Wu, Panpan, Chen, Yingshan, Shen, Ding, Yang, Yang, Zhang, Bingjie, Taylor, Mark J
et al (show 4 more authors) (2017) Synthesis and structure-activity relationship of <i>N</i><SUP>4</SUP>-benzylamine-<i>N</i><SUP>2</SUP>-isopropyl-quinazoline-2,4-diamines derivatives as potential antibacterial agents. RSC ADVANCES, 7 (82). pp. 52227-52237.


Amporndanai, Kangsa, Pinthong, Nattapon ORCID: 0000-0002-0740-9496, O'Neill, Paul M, Hong, W David, Amewu, Richard K ORCID: 0000-0002-4676-436X, Pidathala, Chandrakala, Berry, Neil G ORCID: 0000-0003-1928-0738, Leung, Suet C, Ward, Stephen A, Biagini, Giancarlo A
et al (show 2 more authors) (2022) Targeting the Ubiquinol-Reduction (Q<sub>i</sub>) Site of the Mitochondrial Cytochrome <i>bc<sub>1</sub></i> Complex for the Development of Next Generation Quinolone Antimalarials. BIOLOGY-BASEL, 11 (8). 1109-.


Nixon, Gemma L ORCID: 0000-0002-9730-0960, Pidathala, Chandrakala, Shone, Alison E, Antoine, Thomas, Fisher, Nicholas, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Ward, Stephen A and Biagini, Giancarlo A
(2013) Targeting the mitochondrial electron transport chain of <i>Plasmodium falciparum</i>: new strategies towards the development of improved antimalarials for the elimination era. FUTURE MEDICINAL CHEMISTRY, 5 (13). pp. 1573-1591.


Hong, W David, O'Neill, Paul M ORCID: 0000-0003-4338-0317, Taylor, Mark J, Turner, Joseph D, Ward, Stephen A, Gusovsky, Fabian, Benayoud, Farid, Shibuguchi, Nao, Girish, Dixit, Fang, Francis Gerard
et al (show 9 more authors) (2023) Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis. ORGANIC PROCESS RESEARCH & DEVELOPMENT, 27 (1). pp. 42-53.


Wu, Pan-Pan, He, Hao, Hong, W David, Wu, Tong-Rong, Huang, Gui-Ying, Zhong, Ying-Ying, Tu, Bo-Rong, Gao, Min, Zhou, Jun, Zhao, Su-Qing
et al (show 6 more authors) (2018) The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents. INFECTION AND DRUG RESISTANCE, 11. pp. 1945-1957.


Quek, Shannon, Cook, Darren AN, Wu, Yang, Marriott, Amy E, Steven, Andrew, Johnston, Kelly L, Ford, Louise, Archer, John, Hemingway, Janet, Ward, Stephen A
et al (show 3 more authors) (2022) <i>Wolbachia</i> depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119 (15). e2120003119-.


Yu, Pan, Yang, Jia-Ning, Yan, Jin-Wu, Meng, Zhi-Zhong, Hong, W David, Roberts, Adam P, Ward, Stephen A, Zhang, Lei and Li, Shan
(2020) A novel fluorescent probe for the detection of AmpC beta-lactamase and the application in screening beta-lactamase inhibitors. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 234. 118257-.

This list was generated on Fri Feb 9 11:35:26 2024 GMT.