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Copple, Ian M ORCID: 0000-0003-4101-1913, den Hollander, Wouter, Callegaro, Giulia, Mutter, Fiona E, Maggs, James L, Schofield, Amy L, Rainbow, Lucille ORCID: 0000-0003-0447-6885, Fang, Yongxiang ORCID: 0000-0002-4514-5292, Sutherland, Jeffrey J, Ellis, Ewa C et al (show 6 more authors)
(2019)
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Archives of Toxicology, 93 (2).
pp. 385-399.
Copple, Ian M ORCID: 0000-0003-4101-1913, Mercer, Amy E ORCID: 0000-0002-7399-8655, Firman, James, Donegan, Gail, Herpers, Bram, Wong, Michael HL, Chadwick, James, Bringela, Andreia D, Cristiano, Maria LS, van de Water, Bob et al (show 3 more authors)
(2012)
Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials.
MOLECULAR MEDICINE, 18 (7).
pp. 1045-1055.
Weaver, Richard J, Blomme, Eric A, Chadwick, Amy E ORCID: 0000-0002-7399-8655, Copple, Ian M ORCID: 0000-0003-4101-1913, Gerets, Helga HJ, Goldring, Christopher E, Guillouzo, Andre, Hewitt, Philip G, Ingelman-Sundberg, Magnus, Jensen, Klaus Gjervig et al (show 12 more authors)
(2020)
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
NATURE REVIEWS DRUG DISCOVERY, 19 (2).
pp. 131-148.
Oppelt, Angela, Kaschek, Daniel, Huppelschoten, Suzanna, Sison-Young, Rowena, Zhang, Fang, Buck-Wiese, Marie, Herrmann, Franziska, Malkusch, Sebastian, Kruger, Carmen L, Meub, Mara et al (show 12 more authors)
(2018)
Model-based identification of TNFα-induced IKKβ-mediated and IκBα-mediated regulation of NFκB signal transduction as a tool to quantify the impact of drug-induced liver injury compounds.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 4 (1).
23-.