Meta-analysis of molecular imaging of serotonin transporters in ecstasy/polydrug users

Roberts, CA ORCID: 0000-0003-4275-601X, Jones, A and Montgomery, C (2016) Meta-analysis of molecular imaging of serotonin transporters in ecstasy/polydrug users. Neuroscience and Biobehavioral Reviews, 63. pp. 158-167.

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Abstract

© 2016 The Authors.We conducted a meta-analysis on the available data from studies investigating SERTs in ecstasy users and polydrug using controls. From 7 studies we compared data from 157 ecstasy users and 148 controls across 14 brain regions. The main effect suggested ecstasy/MDMA related SERT reductions (SMD = 0.52, 95% CIs [0.40, 0.65]; Z = 8.36, p < .01, I2 = 89%). A significant effect of subgroups (X2 = 37.41, df = 13, p < .01, I2 = 65.3%) suggested differential effects across brain ROIs. Ecstasy users showed significant SERT reductions in 11 out of the 14 regions, including every neocortical and limbic region analysed. Greatest effects were observed in the occipital cortex (SMD = 1.09, 95% CIs [0.70, 1.48]). No group effects were observed in subcortical areas of the caudate, putamen and midbrain. Literature on Postsynaptic 5HT2A receptor imaging was synthesised with these results. We conclude that, in line with preclinical data, serotonin axons with the longest projections from the raphe nuclei appear to be most affected by ecstasy/MDMA use.

Item Type:	Article
Uncontrolled Keywords:	ecstasy, MDMA, serotonin, SERT, PET, SPECT, Meta-analysis, molecular imaging
Depositing User:	Symplectic Admin
Date Deposited:	12 Apr 2016 11:34
Last Modified:	15 Dec 2022 16:51
DOI:	10.1016/j.neubiorev.2016.02.003
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3000476