Statistical primer: sample size and power calculations-why, when and how?

Hickey, Graeme L ORCID: 0000-0002-4989-0054, Grant, Stuart W, Dunning, Joel and Siepe, Matthias ORCID: 0000-0003-3305-9343 (2018) Statistical primer: sample size and power calculations-why, when and how? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 54 (1). pp. 4-9.

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Abstract

When designing a clinical study, a fundamental aspect is the sample size. In this article, we describe the rationale for sample size calculations, when it should be calculated and describe the components necessary to calculate it. For simple studies, standard formulae can be used; however, for more advanced studies, it is generally necessary to use specialized statistical software programs and consult a biostatistician. Sample size calculations for non-randomized studies are also discussed and two clinical examples are used for illustration.

Item Type:	Article
Uncontrolled Keywords:	Humans, Data Interpretation, Statistical, Sample Size, Research Design, Software, Patient Dropouts, Clinical Trials as Topic
Depositing User:	Symplectic Admin
Date Deposited:	04 Apr 2018 06:20
Last Modified:	19 Jan 2023 06:36
DOI:	10.1093/ejcts/ezy169
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3019759