Improved analgesia by correction of hypomagnesaemia?

Coyle, Seamus ORCID: 0000-0002-4761-9703 and Monnery, Daniel (2018) Improved analgesia by correction of hypomagnesaemia? BMJ SUPPORTIVE & PALLIATIVE CARE, 8 (3). pp. 294-296.

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Abstract

The role of magnesium as an analgesic in patients is unclear. Hypomagnesaemia is a common electrolyte abnormality, in the chronic state symptoms are insidious and often non-specific. It is often undiagnosed and thus untreated. There is evidence from animal studies that magnesium is involved in pain control including an animal model of hyperalgesia induced by hypomagnesaemia. We report two cases of patients admitted for pain control which improved when hypomagnesaemia was treated. Each case had metastatic cancer. Both were found on admission to have asymptomatic hypomagnesaemia and were treated with intravenous magnesium. Treatment for hypomagnesaemia resulted in an improvement in pain control such that analgesia was decreased. The incidence of hypomagnesaemia in palliative patients is unknown although it is thought to be common. These cases suggest that treating hypomagnesaemia may improve pain control.

Item Type:	Article
Uncontrolled Keywords:	Animals, Humans, Neoplasms, Magnesium Deficiency, Magnesium, Analgesics, Treatment Outcome, Analgesia, Aged, Middle Aged, Male, Administration, Intravenous
Depositing User:	Symplectic Admin
Date Deposited:	04 Jul 2018 15:42
Last Modified:	19 Jan 2023 01:31
DOI:	10.1136/bmjspcare-2018-001565
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3023354