Cystic fibrosis related diabetes is not independently associated with increased <i>Stenotrophomonas maltophilia</i> infection: Longitudinal data from updates the UK CF Registry

Frost, Freddy ORCID: 0000-0002-3902-6502, Nazareth, Dilip ORCID: 0000-0002-6114-0467, Shaw, Matthew ORCID: 0000-0001-9184-5591 and Walshaw, Martin J (2019) Cystic fibrosis related diabetes is not independently associated with increased <i>Stenotrophomonas maltophilia</i> infection: Longitudinal data from updates the UK CF Registry. JOURNAL OF CYSTIC FIBROSIS, 18 (2). pp. 294-298.

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Official URL: http://dx.doi.org/10.1016/j.jcf.2018.10.011

Abstract

<h4>Introduction</h4>Stenotrophomonas maltophilia is common in the sputum of people with cystic fibrosis related diabetes (CFRD), raising the question as to whether this is a risk factor for its acquisition. We investigated this at a population level.<h4>Methods</h4>We analysed national Cystic Fibrosis Registry data 2011-2015 for 8047 people with CF > age 6 years, looking at demographics, diagnosis of CFRD, lung function and sputum microbiology; using descriptive and multivariate strategies to establish independent predictors for S. maltophilia culture and associated outcomes.<h4>Results</h4>S. maltophilia was present in 1148 (14.1%). Although univariate analysis confirmed it was more prevalent in those with CFRD, when adjusted for other clinical parameters there was no longer a relationship. Markers of more severe lung disease were independent risk-factors for S. maltophilia.<h4>Conclusion</h4>Although S. maltophilia is more common in people with CFRD, it is not an independent risk-factor for S. maltophilia acquisition.

Item Type:	Article
Uncontrolled Keywords:	Sputum, Humans, Stenotrophomonas maltophilia, Gram-Negative Bacterial Infections, Respiratory Tract Infections, Cystic Fibrosis, Diabetes Mellitus, Respiratory Function Tests, Severity of Illness Index, Registries, Prevalence, Risk Factors, Adolescent, Adult, Female, Male, United Kingdom, Correlation of Data, Outcome Assessment, Health Care
Depositing User:	Symplectic Admin
Date Deposited:	04 Dec 2018 14:56
Last Modified:	07 Feb 2024 20:20
DOI:	10.1016/j.jcf.2018.10.011
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3029469