Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies

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Yao, Linbo, Cheng, Chunru, Yang, Xinmin, Han, Chenxia, Du, Dan, Liu, Tingting, Chvanov, Michael, Windsor, John, Sutton, Robert ORCID: 0000-0001-6600-562X, Huang, Wei et al (show 1 more authors) and Xia, Qing (2019) Ethyl pyruvate and analogs as potential treatments for acute pancreatitis: A review of in vitro and in vivo studies. PANCREATOLOGY, 19 (2). pp. 209-216.

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Official URL: http://dx.doi.org/10.1016/j.pan.2018.12.007

Abstract

Ethyl pyruvate (EP) has been shown to improve outcomes from multiple organ dysfunction syndrome (MODS) in experimental animal models of critical illness. This review aimed to summarise in vitro and in vivo effects of EP analogs on acute pancreatitis (AP) with the objective of proposing medicinal chemistry modifications of EP for future research. In vitro studies showed that both sodium pyruvate and EP significantly reduced pancreatic acinar necrotic cell death pathway activation induced by multiple pancreatic toxins. In vivo studies using different murine AP models showed that EP (usually at a dose of 40 mg/kg every 6 h) consistently reduced pain, markers of pancreatic injury, systemic inflammation and MODS. There was also a significant increase in survival rate, even when EP was administered 12 h after disease induction (compared with untreated groups or those treated with Ringer's lactate solution). Experimental studies suggest that EP and analogs are promising drug candidates for treating AP. EP or analogs can undergo medicinal chemistry modifications to improve its stability and deliverability. EP or analogs could be evaluated as a supplement to intravenous fluid therapy in AP.

Item Type:	Article
Uncontrolled Keywords:	Acute pancreatitis, Pancreatic acinar cells, Ethyl pyruvate, Medicinal chemistry, Fluid therapy
Depositing User:	Symplectic Admin
Date Deposited:	13 Mar 2019 15:15
Last Modified:	14 Oct 2023 09:04
DOI:	10.1016/j.pan.2018.12.007
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3034179