Arrowsmith, S
(2019)
Oxytocin and vasopressin signalling and myometrial contraction.
Current opinion in physiology, 13.
pp. 62-70.
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Abstract
Oxytocin and vasopressin are potent stimulants of uterine contractions. The importance of these hormones, particularly oxytocin, in pregnancy and labour, has been extensively studied and has paved the way for many important discoveries focused on the management of uterine contractions in labour. This includes development of therapies modelled on their structure or drug-delivery strategies targeting their receptors. This review will summarise our current knowledge of oxytocin and vasopressin signalling in myometrium and describe recent advances which have shed light on their roles in parturition, including novel roles for oxytocin as an inflammatory mediator and a regulator of gene transcription. How this information may impact the development and delivery of new oxytocin receptor-focussed therapies for preterm birth and dysfunctional labour will be discussed. Issues that warrant further investigation and which are necessary for expanding the therapeutic potential of these important signalling molecules are also highlighted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Preterm, Low Birth Weight and Health of the Newborn, Contraception/Reproduction, Pediatric, Infant Mortality, Genetics, Perinatal Period - Conditions Originating in Perinatal Period, Reproductive health and childbirth |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 18 Oct 2019 10:11 |
| Last Modified: | 15 Mar 2024 08:09 |
| DOI: | 10.1016/j.cophys.2019.10.006 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3058598 |
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