Staton, Gareth James, Sullivan, Leigh Emma, Blowey, Roger W, Carter, Stuart D and Evans, Nicholas James ORCID: 0000-0002-2950-1007
(2020)
Surveying bovine digital dermatitis and non-healing bovine foot lesions for the presence of Fusobacterium necrophorum, Porphyromonas endodontalis and Treponema pallidum.
The Veterinary record.
There is a more recent version of this item available. |
Abstract
BACKGROUND:Non-healing bovine foot lesions, including non-healing white line disease, non-healing sole ulcer and toe necrosis, are an increasingly important cause of chronic lameness that are poorly responsive to treatment. Recent studies have demonstrated a high-level association between these non-healing lesions and the Treponema phylogroups implicated in bovine digital dermatitis (BDD). However, a polymicrobial aetiology involving other gram-stain-negative anaerobes is suspected. METHODS:A PCR-based bacteriological survey of uncomplicated BDD lesions (n=10) and non-healing bovine foot lesions (n=10) targeting Fusobacterium necrophorum, Porphyromonas endodontalis, Dichelobacter nodosus and Treponema pallidum/T. paraluiscuniculi was performed. RESULTS:P. endodontalis DNA was detected in 80.0% of the non-healing lesion biopsies (p=<0.001) but was entirely absent from uncomplicated BDD lesion biopsies. When compared to the BDD lesions, F. necrophorum was detected at a higher frequency in the non-healing lesions (33.3% vs 70.0%, respectively), whereas D. nodosus was detected at a lower frequency (55.5% vs 20.0%, respectively). Conversely, T. pallidum/T. paraluiscuniculi DNA was not detected in either lesion type. CONCLUSION:The data from this pilot study suggest that P. endodontalis and F. necrophorum should be further investigated as potential aetiological agents of non-healing bovine foot lesions. A failure to detect syphilis treponemes in either lesion type is reassuring given the potential public health implications such an infection would present.
Item Type: | Article |
---|---|
Depositing User: | Symplectic Admin |
Date Deposited: | 02 Mar 2020 11:21 |
Last Modified: | 19 Jan 2023 00:00 |
DOI: | 10.1136/vr.105628 |
Open Access URL: | https://veterinaryrecord.bmj.com/content/early/202... |
URI: | https://livrepository.liverpool.ac.uk/id/eprint/3076905 |
Available Versions of this Item
- Surveying bovine digital dermatitis and non-healing bovine foot lesions for the presence of Fusobacterium necrophorum, Porphyromonas endodontalis and Treponema pallidum. (deposited 02 Mar 2020 11:21) [Currently Displayed]