Cardiac rehabilitation meta-analysis of trials in patients with coronary heart disease using individual participant data (CaReMATCH): Project protocol

Buckley, Benjamin JR ORCID: 0000-0002-1479-8872, Kleinnibbelink, Geert, Lip, Gregory YH ORCID: 0000-0002-7566-1626, Taylor, Rod S and Thijssen, Dick HJ (2020) Cardiac rehabilitation meta-analysis of trials in patients with coronary heart disease using individual participant data (CaReMATCH): Project protocol. IJC Heart & Vasculature, 31. p. 100616.

Text IJCHA-D-20-00028 R1.docx - Author Accepted Manuscript Download (91kB)

Abstract

<h4>Background</h4>Exercise-based cardiac rehabilitation (CR) has long been a cornerstone in the secondary prevention of coronary heart disease (CHD). Despite meta-analyses of randomised trials demonstrating a positive impact of CR on cardiovascular mortality, hospitalisation, exercise capacity and health related quality of life, the impact of CR on all-cause mortality remains uncertain, especially in the context of contemporary clinical practice. This CR meta-analysis of trials in patients with coronary heart disease using individual participant data (IPD) (CaReMATCH) seeks to (1) provide definitive estimates of the effectiveness of CR in terms of all-cause mortality, cardiovascular mortality, hospitalisation and health-related quality of life, and (2) determine the influence of individual patient characteristics (e.g. age, sex, risk factors) on the effectiveness of CR to inform a personalised CR-approach.<h4>Methods</h4>Randomised controlled trials will be identified that were performed in the last decade, to ensure that CR was performed in combination with contemporary medical care (2010-2020). For our first aim, outcomes of interest include all cause- and CVD-related mortality and hospitalisations. To answer our second research question, we will collect data on exercise capacity, health-related quality of life, and patient baseline demographic and clinical data. Original IPD will be requested from the authors of all eligible trials; we will check original data and compile a master dataset. IPD meta-analyses will be conducted using a one-step meta-analysis approach where the IPD from all studies are modelled simultaneously whilst accounting for the clustering of participants within studies.<h4>Discussion</h4>Findings from CaReMATCH will inform future (inter)national clinical and policy decision-making on the (personalised) application of exercise-based CR for patients with CHD.

Item Type:	Article
Uncontrolled Keywords:	Cardiac rehabilitation, Exercise as medicine, Individual patient data, Meta-analysis, Protocol, Coronary heart disease
Depositing User:	Symplectic Admin
Date Deposited:	16 Sep 2020 11:16
Last Modified:	18 Jan 2023 23:33
DOI:	10.1016/j.ijcha.2020.100616
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3101405