Nelson, Alexandra Jayne, Johnston, Brian W 
ORCID: 0000-0003-1634-3297, Waite, Alicia Achiaa Charlotte ORCID: 0000-0001-8734-994X, Lemma, Gedeon and Welters, Ingeborg Dorothea ORCID: 0000-0001-8734-994X
(2021)
A Systematic Review of Anticoagulation Strategies for Patients With Atrial Fibrillation in Critical Care.
Thrombosis and Haemostasis, 121 (12).
pp. 1599-1609.
|
Text
FINAL TH ARTICLE NO TRACKING.pdf - Author Accepted Manuscript Download (575kB) | Preview |
Abstract
<jats:p>Background. Atrial fibrillation (AF) is the most common cardiac arrhythmia in critically ill patients. There is a paucity of data assessing the impact of anticoagulation strategies on clinical outcomes for general critical care patients with AF. Our aim was to assess the existing literature to evaluate the effectiveness of anticoagulation strategies used in critical care for AF. Methodology. A systematic literature search was conducted using MEDLINE, EMBASE, CENTRAL and PubMed databases. Studies reporting anticoagulation strategies for AF in adults admitted to a general critical care setting were assessed for inclusion. Results. Four studies were selected for data extraction. A total of 44087 patients were identified with AF, of which 17.8-49.4% received anticoagulation. The reported incidence of thromboembolic events was 0-1.4% for anticoagulated patients, and 0-1.3% in non-anticoagulated patients. Major bleeding events were reported in three studies and occurred in 7.2-8.6% of the anticoagulated patients and up to 7.1% of the non-anticoagulated patients. Conclusions. There was an increased incidence of major bleeding events in anticoagulated patients with AF in critical care compared to non-anticoagulated patients. There was no significant difference in the incidence of reported thromboembolic events within studies, between patients who did and did not receive anticoagulation. However, the outcomes reported within studies were not standardised, therefore, the generalisability of our results to the general critical care population remains unclear. Further data is required to facilitate an evidence-based assessment of the risks and benefits of anticoagulation for critically ill patients with AF. </jats:p>
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | atrial fibrillation, anticoagulation, critical care, intensive care, new-onset AF |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Clinical Directorate Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 19 Apr 2021 13:48 |
| Last Modified: | 10 Mar 2023 08:35 |
| DOI: | 10.1055/a-1477-3760 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3119068 |
Dimensions
Dimensions
