Should all babies with oesophageal atresia have routine screening for midgut malrotation anomalies? A systematic review in search of evidence

Green, Patrick A, Nicoara, Cezar D and Losty, Paul D ORCID: 0000-0003-0841-5879 (2022) Should all babies with oesophageal atresia have routine screening for midgut malrotation anomalies? A systematic review in search of evidence. JOURNAL OF PEDIATRIC SURGERY, 57 (4). pp. 655-660.

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Abstract

Background/Purpose Oesophageal Atresia (OA) is associated with co-existent anomalies. There is a controversy of literature pertaining to the risk (s) of intestinal malrotation. In order to guide management we critically evaluate the incidence of IM anomalies in OA newborns. Design MEDLINE and EMBASE databases were searched using keywords "(O)Esophageal Atresia and Malrotation/Associated Abnormalities/Associated Anomalies". Full texts of articles were screened if manuscripts exclusively reported patients with OA malrotation and/or associated anomalies. Larger case series (> 10patients) were included if abstract (s) showed that associated anomalies were systematically assessed. Full eligibility criteria required at least one case of malrotation in an OA index case. Data were collected on article type, number of patients and method (s) of diagnosis. Results 632 abstracts were screened of which 158 papers were analysed based on inclusion criteria-30 manuscripts documented the incidence (%) of malrotation. Incidence rate (s) were 0.5-13%. Malrotation was observed to have a higher incidence (10-44%) in OA babies with other gastrointestinal anomalies (VACTERL). Conclusion Newborns with OA appear to be at a higher risk (%) of having intestinal malrotation anomalies than healthy babies. Prospective studies are required to accurately quantify and define the ' true incidence ' of this association. Given the potential lethal consequences of midgut volvulus screening may be justified in OA babies. Consensus guidelines (DELPHI) exploring surgeons attitudes with regards management of ' asymptomatic malrotation ' disorders in OA newborns may further guide best practice.

Item Type:	Article
Uncontrolled Keywords:	Oesophageal atresia, Malrotation, Newborn, Oesophageal atresia, Malrotation, Newborn
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	10 Jun 2021 07:35
Last Modified:	18 Jan 2023 22:35
DOI:	10.1016/j.jpedsurg.2021.06.005
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3125737