Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group.

Ramanan, Athimalaipet V ORCID: 0000-0001-8663-2401, Modi, Neena, de Wildt, Saskia N and c4c Learning from COVID-19 Group, (2022) Improving clinical paediatric research and learning from COVID-19: recommendations by the Conect4Children expert advice group. Pediatric research, 91 (5). pp. 1069-1077.

	Text Improving clinical paediatric research and learning from COVID-19 recommendations by the Conect4Children expert advice group.pdf - Published version Download (723kB) | Preview
	Text C4CRamMarked copy31March2021 DH.docx - Author Accepted Manuscript Download (95kB)

Abstract

<h4>Background</h4>The COVID-19 pandemic has had a devastating impact on multiple aspects of healthcare, but has also triggered new ways of working, stimulated novel approaches in clinical research and reinforced the value of previous innovations. Conect4children (c4c, www.conect4children.org ) is a large collaborative European network to facilitate the development of new medicines for paediatric populations, and is made up of 35 academic and 10 industry partners from 20 European countries, more than 50 third parties, and around 500 affiliated partners.<h4>Methods</h4>We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equity.<h4>Findings</h4>We summarise aspects of clinical research in paediatrics stimulated and reinforced by COVID-19 that the Conect4children group recommends regulators, sponsors, and investigators retain for the future, to enhance the efficiency, reduce the cost and burden of medicines and non-interventional studies, and deliver research-equityWe provide examples of research innovation, and follow this with recommendations to improve the efficiency of future trials, drawing on industry perspectives, regulatory considerations, infrastructure requirements and parent-patient-public involvement. We end with a comment on progress made towards greater international harmonisation of paediatric research and how lessons learned from COVID-19 studies might assist in further improvements in this important area.

Item Type:	Article
Uncontrolled Keywords:	c4c Learning from COVID-19 Group, Humans, Pediatrics, Research, Child, Europe, Pandemics, COVID-19
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	01 Feb 2022 09:52
Last Modified:	18 Jan 2023 21:14
DOI:	10.1038/s41390-021-01587-3
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3147940