Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota

Drozdz, Karolina, Nabrdalik, Katarzyna, Hajzler, Weronika, Kwiendacz, Hanna, Gumprecht, Janusz and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2022) Metabolic-Associated Fatty Liver Disease (MAFLD), Diabetes, and Cardiovascular Disease: Associations with Fructose Metabolism and Gut Microbiota. NUTRIENTS, 14 (1). 103-.

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Official URL: http://dx.doi.org/10.3390/nu14010103

Abstract

Non-alcoholic fatty liver disease (NAFLD) is an increasingly common condition associated with type 2 diabetes (T2DM) and cardiovascular disease (CVD). Since systemic metabolic dysfunction underlies NAFLD, the current nomenclature has been revised, and the term metabolic-associated fatty liver disease (MAFLD) has been proposed. The new definition emphasizes the bidirectional relationships and increases awareness in looking for fatty liver disease among patients with T2DM and CVD or its risk factors, as well as looking for these diseases among patients with NAFLD. The most recommended treatment method of NAFLD is lifestyle changes, including dietary fructose limitation, although other treatment methods of NAFLD have recently emerged and are being studied. Given the focus on the liver-gut axis targeting, bacteria may also be a future aim of NAFLD treatment given the microbiome signatures discriminating healthy individuals from those with NAFLD. In this review article, we will provide an overview of the associations of fructose consumption, gut microbiota, diabetes, and CVD in patients with NAFLD.

Item Type:	Article
Uncontrolled Keywords:	metabolic-associated fatty liver disease, diabetes mellitus, cardiovascular disease, fructose, microbiota
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	13 May 2022 14:36
Last Modified:	18 Jan 2023 21:03
DOI:	10.3390/nu14010103
Open Access URL:	https://www.mdpi.com/2072-6643/14/1/103
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3154753