Li, Shun, Pritchard, David Mark 
ORCID: 0000-0001-7971-3561 and Yu, Lu-Gang ORCID: 0000-0001-9641-3712
(2022)
Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis.
CANCERS, 14 (13).
3263-.
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Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis.pdf - Published version Download (1MB) | Preview |
Abstract
Matrix metalloproteinase-13 (MMP-13) is a member of the Matrix metalloproteinases (MMPs) family of endopeptidases. MMP-13 is produced in low amounts and is well-regulated during normal physiological conditions. Its expression and secretion are, however, increased in various cancers, where it plays multiple roles in tumour progression and metastasis. As an interstitial collagenase, MMP-13 can proteolytically cleave not only collagens I, II and III, but also a range of extracellular matrix proteins (ECMs). Its action causes ECM remodelling and often leads to the release of various sequestered growth and angiogenetic factors that promote tumour cell growth, invasion and angiogenesis. This review summarizes our current understanding of the regulation of MMP-13 expression and secretion and discusses the actions of MMP-13 in cancer progression and metastasis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MMP-13, tumour growth, cancer invasion, metastasis, angiogenesis |
| Divisions: | Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology |
| Depositing User: | Symplectic Admin |
| Date Deposited: | 09 Sep 2022 10:02 |
| Last Modified: | 18 Jan 2023 20:45 |
| DOI: | 10.3390/cancers14133263 |
| Related URLs: | |
| URI: | https://livrepository.liverpool.ac.uk/id/eprint/3163997 |
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