Outcomes in patients with ischaemic stroke undergoing endovascular thrombectomy: Impact of atrial fibrillation

Alobaida, Muath ORCID: 0000-0003-1257-1428, Harrison, Stephanie L ORCID: 0000-0002-8846-0946, Lane, Deirdre A ORCID: 0000-0002-5604-9378, Underhill, Paula, Hill, Andrew and Lip, Gregory YH ORCID: 0000-0002-7566-1626 (2023) Outcomes in patients with ischaemic stroke undergoing endovascular thrombectomy: Impact of atrial fibrillation. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 32 (2). 106917-.

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Abstract

<h4>Objectives</h4>Endovascular thrombectomy (EVT) is associated with good clinical outcomes in ischaemic stroke, but the risk of intracerebral haemorrhage (ICH) and mortality remains common following ischaemic stroke. The effect of concomitant atrial fibrillation (AF) on clinical outcomes following acute ischaemic stroke in patients receiving EVT remains unclear. The aim is to investigate associations between AF and intracerebral haemorrhage and all-cause mortality at 90 days in patients with ischaemic stroke undergoing EVT.<h4>Materials and methods</h4>A retrospective cohort was conducted using TriNetX, a global health research network. The network was searched for people aged ≥18 years with ischaemic stroke, EVT and AF recorded in electronic medical records between 01/09/2018 and 01/09/2021. These patients were compared to controls with ischaemic stroke, EVT and no AF. Propensity score matching for age, sex, race, comorbidities, National Institutes of Health Stroke Scale (NIHSS) scores, and prior use of anticoagulation was used to balance the cohorts with and without AF.<h4>Results</h4>In total 3,106 patients were identified with history of ischaemic stroke treated by EVT. After propensity-score matching, 832 patients (mean age 68 ± 13; 47% female) with ischaemic stroke, EVT and AF, were compared to 832 patients (mean age 67 ± 12; 47% female) with ischaemic stroke, EVT and no history of AF. In the cohort with AF, 11.5% (n = 96) experienced ICH within 90 days following EVT, compared with 12.3% (n = 103) in patients without AF (Odds Ratio (OR) 0.92, 95% confidence interval (CI) 0.68-1.24; p = 0.59). In the patients with AF, mortality within 90 days following EVT was 18.7% (n = 156), compared with 22.5% in patients without AF (n = 187) (OR 0.79, 95% CI 0.63-1.01; p = 0.06).<h4>Conclusion</h4>In patients with ischaemic stroke undergoing EVT, AF was not significantly associated with intracerebral haemorrhage or all-cause mortality at 90-day follow-up.

Item Type:	Article
Uncontrolled Keywords:	ischaemic stroke, endovascular thrombectomy, atrial fibrillation, intracerebral haemorrhage, clinical outcomes
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	17 Jan 2023 14:24
Last Modified:	21 Jun 2023 12:37
DOI:	10.1016/j.jstrokecerebrovasdis.2022.106917
Open Access URL:	https://doi.org/10.1016/j.jstrokecerebrovasdis.202...
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3167101