Long term quality of life outcomes following surgical resection alone for benign paediatric intracranial tumours

Kumar, Siddhant ORCID: 0000-0001-8084-2504, Islim, Abdurrahman II, Moon, Richard, Millward, Christopher PP ORCID: 0000-0001-7727-1157, Hennigan, Dawn, Thorpe, Antonia, Foster, Mitchell, Pizer, Barry, Mallucci, Conor LL and Jenkinson, Michael DD ORCID: 0000-0003-4587-2139 (2023) Long term quality of life outcomes following surgical resection alone for benign paediatric intracranial tumours. , United States.

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Abstract

<h4>Purpose</h4>Survivors of paediatric intracranial tumours are at increased risk of psychosocial, neuro-developmental, and functional impairment. This study aimed to evaluate long-term health-related quality-of-life (HRQOL) outcomes in patients with benign paediatric brain tumours treated curatively with surgical resection alone.<h4>Methodology</h4>This was a cross-sectional study of patients with benign paediatric intracranial tumours managed with surgery alone between 2000 and 2015. Eligible patients with a minimum of 5-years follow-up after surgery were identified. Validated health-related quality of life (HRQOL) questionnaires were administered: SF-36, QLQ-BN20, QLQ-C30 and PedsQL™.<h4>Results</h4>Twenty-three patients participated (median age at surgery 13 years; range 1-18; 12 male). The most common diagnosis was pilocytic astrocytoma (n = 15). Median time from surgery to participation was 11 years(range 6-19). Fourteen patients achieved A-level qualifications and two obtained an undergraduate degree. Twelve patients were employed, eight were studying and three were unemployed or volunteering. HRQOL outcomes demonstrated significant limitation from social functioning (p = 0.03) and cognitive functioning (p = 0.023) compared to the general population. Patients also experienced higher rates of loss of appetite (p = 0.009) and nausea and vomiting (p = 0.031). Ten patients were under transitional teenager and young-adult (TYA) clinic follow-up. TYA patients achieved higher levels of education (p = 0.014), were more likely to hold a driver's license (p = 0.041) compared to patients not followed-up through these services.<h4>Conclusions</h4>Childhood brain-tumour survivors have a greater risk of developing psychological, neuro-cognitive and physical impairment. Early comprehensive assessment, specialist healthcare and TYA services are vital to support these patients.

Item Type:	Conference or Workshop Item (Unspecified)
Uncontrolled Keywords:	Benign, Brain tumours, Childood, Quality of life, Surgery, Survivors
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences > School of Medicine Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User:	Symplectic Admin
Date Deposited:	19 May 2023 09:18
Last Modified:	02 Jan 2024 02:30
DOI:	10.1007/s11060-022-04208-z
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3170531