Total and Unbound Bictegravir Concentrations and Viral Suppression in Cerebrospinal Fluid of Human Immunodeficiency Virus-Infected Patients (Spanish HIV/AIDS Research Network, PreEC/RIS 56)


Tiraboschi, Juan, Imaz, Arkaitz, Khoo, Saye ORCID: 0000-0002-2769-0967, Niubo, Jordi, Prieto, Paula, Saumoy, Maria, Penchala, Sujan Dilly, Garcia, Benito, Padilla, Cristina, Videla, Sebastian et al (show 1 more authors) (2020) Total and Unbound Bictegravir Concentrations and Viral Suppression in Cerebrospinal Fluid of Human Immunodeficiency Virus-Infected Patients (Spanish HIV/AIDS Research Network, PreEC/RIS 56). JOURNAL OF INFECTIOUS DISEASES, 221 (9). pp. 1425-1428.

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Abstract

We determined total and unbound concentrations of bictegravir (BIC) in cerebrospinal fluid (CSF) in 15 asymptomatic, virologically suppressed patients. The median plasma and CSF total BIC concentrations were 1837.1 ng/mL (interquartile range [IQR], 1237.2-2586.7) and 6.9 (IQR, 4.8-10.9), respectively. Median unbound BIC concentration was 2.48 ng/mL (IQR, 1.6-3.7). Total and unbound BIC CSF concentrations were above the half-maximal effective concentration value in all patients, and all subjects had human immunodeficiency virus viral suppression in plasma and CSF. Bictegravir may contribute to inhibit viral replication in this compartment.

Item Type: Article
Uncontrolled Keywords: bictegravir, CNS, concentrations, unbound
Divisions: Faculty of Health and Life Sciences
Faculty of Health and Life Sciences > Institute of Systems, Molecular and Integrative Biology
Depositing User: Symplectic Admin
Date Deposited: 26 May 2023 07:14
Last Modified: 26 May 2023 07:14
DOI: 10.1093/infdis/jiz624
Related URLs:
URI: https://livrepository.liverpool.ac.uk/id/eprint/3170700
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