cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases

Carlsson, Emil, Cowell-McGlory, Taylor and Hedrich, Christian M ORCID: 0000-0002-1295-6179 (2023) cAMP responsive element modulator α promotes effector T cells in systemic autoimmune diseases. IMMUNOLOGY, 170 (4). pp. 470-482.

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Abstract

T lymphocytes play a crucial role in adaptive immunity. Dysregulation of T cell-derived inflammatory cytokine expression and loss of self-tolerance promote inflammation and tissue damage in several autoimmune/inflammatory diseases, including systemic lupus erythematosus (SLE) and psoriasis. The transcription factor cAMP responsive element modulator α (CREMα) plays a key role in the regulation of T cell homeostasis. Increased expression of CREMα is a hallmark of the T cell-mediated inflammatory diseases SLE and psoriasis. Notably, CREMα regulates the expression of effector molecules through trans-regulation and/or the co-recruitment of epigenetic modifiers, including DNA methyltransferases (DNMT3a), histone-methyltransferases (G9a) and histone acetyltransferases (p300). Thus, CREMα may be used as a biomarker for disease activity and/or target for future targeted therapeutic interventions.

Item Type:	Article
Uncontrolled Keywords:	CREM, epigenetics, lymphocyte, psoriasis, psoriatic arthritis, systemic lupus erythematosus
Divisions:	Faculty of Health and Life Sciences Faculty of Health and Life Sciences > Institute of Life Courses and Medical Sciences
Depositing User:	Symplectic Admin
Date Deposited:	28 Jul 2023 13:53
Last Modified:	10 Nov 2023 10:45
DOI:	10.1111/imm.13680
Open Access URL:	https://doi.org/10.1111/imm.13680
Related URLs:	Author Publisher
URI:	https://livrepository.liverpool.ac.uk/id/eprint/3171973